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Relationship of the Brief UCSD Performance-based Skills Assessment (UPSA-B) to multiple indicators of functioning in people with schizophrenia and bipolar disorder

Authors


  • PDH has received grant support from AstraZeneca, and in the past year, he has served as a consultant for Eli Lilly & Co., Johnson & Johnson, Merck & Co., Shire Pharma, and Dainippon Sumitomo America. BTM, AEP, CAD, PSW, MHT, JRL, JAM, CB and TLP have no conflicts of interest to report.

Corresponding author:
Brent T. Mausbach, Ph.D.
Department of Psychiatry
University of California at San Diego
9500 Gilman Drive
La Jolla, CA, 92093-0680, USA
Fax: 858-534-7723
E-mail: bmausbach@ucsd.edu

Abstract

Mausbach BT, Harvey PD, Pulver AE, Depp CA, Wolyniec PS, Thornquist MH, Luke JR, McGrath JA, Bowie CR, Patterson TL. Relationship of the Brief UCSD Performance-based Skills Assessment (UPSA-B) to multiple indicators of functioning in people with schizophrenia and bipolar disorder. Bipolar Disord 2010: 12: 45–55. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.

Objective:  This study assessed the relationship between multiple indicators of ‘real-world’ functioning and scores on a brief performance-based measure of functional capacity known as the Brief University of California San Diego (UCSD) Performance-based Skills Assessment (UPSA-B) in a sample of 205 patients with either serious bipolar disorder (n = 89) or schizophrenia (n = 116).

Methods:  Participants were administered the UPSA-B and assessed on the following functional domains: (i) independent living status (e.g., residing independently as head of household, living in residential care facility); (ii) informant reports of functioning (e.g., work skills, daily living skills); (iii) educational attainment and estimated premorbid IQ as measured by years of education and Wide Range Achievement Test reading scores, respectively; and (iv) employment.

Results:  Better scores on the UPSA-B were associated with greater residential independence after controlling for age, diagnosis, and symptoms of psychopathology. Among both bipolar disorder and schizophrenia patients, higher UPSA-B scores were significantly related to better informant reports of functioning in daily living skills and work skills domains. Greater estimated premorbid IQ was associated with higher scores on the UPSA-B for both schizophrenia and bipolar disorder participants. Participants who were employed scored higher on the UPSA-B when controlling for age and diagnosis, but not when controlling for symptoms of psychopathology.

Conclusions:  These data suggest the UPSA-B may be useful for assessing capacity for functioning in a number of domains in both people diagnosed with schizophrenia and bipolar disorder.

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