Anxiety as a symptom of mixed mania: implications for DSM-5


  • FC has received grant/research support from Pfizer, Organon, Corcept, and NARSAD; has participated in advisory boards for Shire; has been a past speaker for Pfizer; and has owned stock in Pfizer.

Corresponding author:
Frederick Cassidy, M.D.
Central Regional Hospital
300 Veazey Road
Butner, NC 27509, USA
Fax: 919-575-7079


Cassidy F. Anxiety as a symptom of mixed mania: implications for DSM-5.
Bipolar Disord 2010: 12: 437–439. © 2010 The Author. Journal compilation © 2010 John Wiley & Sons A/S.

Abstract:  The recently released preliminary proposal for the DSM-5 diagnostic system includes modification of the mixed mania diagnosis symptom set. That definition includes the long-overdue exclusion of nonspecific signs and symptoms, as well as the inclusion of psychomotor retardation. Anxiety is specifically excluded from the definition. The current report reviews studies to establish that psychomotor retardation would have limited utility in the definition, in contrast to anxiety, which is a core symptom of the mixed manic subtype.