The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Theory of mind and neurocognitive functioning in patients with bipolar disorder
Article first published online: 27 SEP 2010
© 2010 John Wiley and Sons A/S
Volume 12, Issue 6, pages 657–666, September 2010
How to Cite
Wolf, F., Brüne, M. and Assion, H.-J. (2010), Theory of mind and neurocognitive functioning in patients with bipolar disorder. Bipolar Disorders, 12: 657–666. doi: 10.1111/j.1399-5618.2010.00854.x
- Issue published online: 27 SEP 2010
- Article first published online: 27 SEP 2010
- Received 17 July 2009, revised and accepted for publication 9 July 2010
- bipolar disorder;
- neurocognitive functioning;
- theory of mind
Wolf F, Brüne M, Assion H-J. Theory of mind and neurocognitive functioning in patients with bipolar disorder. Bipolar Disord 2010: 12: 657–666. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.
Objectives: Studies into social cognition in psychiatric disorders have recently been expanded to address the question of whether or not theory of mind (ToM), i.e., the ability to represent one’s own and others’ mental states, is impaired in bipolar affective disorder (BPD). Results have been mixed so far, mainly due to possible confounding effects of neurocognition, as well as clinical factors such as acuity and current mood. Here, we explored ToM and its associations with neurocognitive functioning in BPD.
Methods: A total of 33 patients with bipolar I disorder (of whom 12 were currently depressed, 10 manic, and 11 remitted) and 29 healthy controls were assessed using a test battery that was identical to the one that was used in previous studies in schizophrenia, comprising diverse neurocognitive tasks, including measures of intelligence, executive functioning, and ToM tasks.
Results: The bipolar disorder patient group as a whole and all three clinical subgroups were impaired on all measures of ToM relative to controls, but did not differ from each other in most ToM scores. Patients’ poorer performance on executive tasks did not fully explain ToM differences between patients and controls, suggesting a partially selective ToM deficit in BPD.
Conclusions: Patients with BPD are impaired in ToM, partially independent of other cognitive dysfunctions and current mood.