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The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis


  • In the last 12 months, SNG has received research grants from Pfizer and NIH. FMD and SBT have no conflicts of interest to disclose.

Corresponding author:
S. Nassir Ghaemi, M.D.
Mood Disorders Program
Department of Psychiatry
Tufts Medical Center
800 Washington Street, #1007
Boston, MA 02111, USA
Fax: 617-636-7795


Daray FM, Thommi SB, Ghaemi SN. The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis.
Bipolar Disord 2010: 12: 702–706. © 2010 The Authors.
Journal compilation © 2010 John Wiley & Sons A/S.

Objective:  Antidepressant-induced mania (AIM) has been associated with the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism in some studies but not in others. We conducted a meta-analysis of those studies and other studies of genetic predictors of AIM.

Methods:  MEDLINE-based searches of genetic studies of AIM were conducted, and a meta-analysis of six studies of 5-HTTLPR was performed. Other polymorphisms were insufficiently studied to allow for meta-analysis.

Results:  There was an association of the short (s) variant of 5-HTTLPR and AIM [risk ratio (RR) = 1.35, 95% confidence interval (CI): 1.04–1.76, p = 0.02]. There was a higher frequency of s carriers (sl and ss genotypes) in those who developed AIM [RR = 1.38, 95% CI: 0.98–1.93), p = 0.06].

Conclusion:  The 5-HTTLPR polymorphism appears to have a moderate effect size association with AIM in patients with bipolar disorder.