SEARCH

SEARCH BY CITATION

Figure S1. Effect of single-nucleotide polymorphism (SNP) rs956572 variation on store- and receptor-operated calcium (Ca2+) entry. (A) thapsigargin (TG)-stimulated responses (difference between the peak of Ca2+ and baseline, Δ[Ca2+]influx). Bipolar I disorder (BD-I) patients with G/G variants showed higher Δ[Ca2+]influx than BD-I A/A variants (1.35-fold) and healthy G/G variants (1.22-fold); however, statistically significant effects were not found for diagnosis [F(1,39) = 0.958, p = 0.334], rs956572 genotype [F(2,39) = 2.200, p = 0.124], or interaction between these factors [F(2,39) = 0.968, p = 0.389]. (B) Lysophosphatidic acid (LPA)-stimulated Ca2+ responses [the slope of the initial rate of rise in LPA-stimulated Ca2+(d[Ca2+]s/dt)]. BD-I patients with G/G variants showed higher d[Ca2+]s/dt than BD-I A/A variants (1.85-fold) and healthy G/G variants (1.55-fold); however, statistically significant effects were not found for diagnosis [F(1,46) = 3.625, p = 0.063], rs956572 genotype [F(2,46) = 2.144, p = 0.129], or interaction between these factors [F(2,46) = 0.416, p = 0.662]. Data are expressed as mean ± SD.

Table S1. Demographic characteristics of bipolar I disorder (BD-I) patients.

Table S2. Genotype frequencies of B-cell CLL/lymphoma 2 (Bcl-2) intronic single-nucleotide polymorphism rs956572 in mood disorder and comparison healthy subject groups.

Table S3. Allele frequencies of B-cell CLL/lymphoma 2 (Bcl-2) intronic single-nucleotide polymorphism rs956572 in mood disorder and comparison healthy subjects groups.

Table S4. Thapsigargin-sensitive endoplasmic reticulum-calcium (Ca2+) release in Ca2+ free medium in bipolar I disorder (BD-I) patients and comparison healthy subjects.

FilenameFormatSizeDescription
BDI_897_sm_FigureS1-TablesS1-S3.doc400KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.