A preliminary report of this work was presented at the 65th Annual Meeting of the Society for Biological Psychiatry, May 20–22, 2010, New Orleans, LA, USA.
Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder
Version of Record online: 14 FEB 2011
© 2011 John Wiley and Sons A/S
Volume 13, Issue 1, pages 41–51, February 2011
How to Cite
Uemura, T., Green, M., Corson, T. W., Perova, T., Li, P. P. and Warsh, J. J. (2011), Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder. Bipolar Disorders, 13: 41–51. doi: 10.1111/j.1399-5618.2011.00897.x
The authors of this paper declare that, except for income received from the primary employer or trainee award, no financial support or compensation has been received from any individual or corporate entity for research or professional service and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest.
- Issue online: 14 FEB 2011
- Version of Record online: 14 FEB 2011
- Received 29 September 2010, revised and accepted for publication 8 December 2010
Figure S1. Effect of single-nucleotide polymorphism (SNP) rs956572 variation on store- and receptor-operated calcium (Ca2+) entry. (A) thapsigargin (TG)-stimulated responses (difference between the peak of Ca2+ and baseline, Δ[Ca2+]influx). Bipolar I disorder (BD-I) patients with G/G variants showed higher Δ[Ca2+]influx than BD-I A/A variants (1.35-fold) and healthy G/G variants (1.22-fold); however, statistically significant effects were not found for diagnosis [F(1,39) = 0.958, p = 0.334], rs956572 genotype [F(2,39) = 2.200, p = 0.124], or interaction between these factors [F(2,39) = 0.968, p = 0.389]. (B) Lysophosphatidic acid (LPA)-stimulated Ca2+ responses [the slope of the initial rate of rise in LPA-stimulated Ca2+(d[Ca2+]s/dt)]. BD-I patients with G/G variants showed higher d[Ca2+]s/dt than BD-I A/A variants (1.85-fold) and healthy G/G variants (1.55-fold); however, statistically significant effects were not found for diagnosis [F(1,46) = 3.625, p = 0.063], rs956572 genotype [F(2,46) = 2.144, p = 0.129], or interaction between these factors [F(2,46) = 0.416, p = 0.662]. Data are expressed as mean ± SD.
Table S1. Demographic characteristics of bipolar I disorder (BD-I) patients.
Table S2. Genotype frequencies of B-cell CLL/lymphoma 2 (Bcl-2) intronic single-nucleotide polymorphism rs956572 in mood disorder and comparison healthy subject groups.
Table S3. Allele frequencies of B-cell CLL/lymphoma 2 (Bcl-2) intronic single-nucleotide polymorphism rs956572 in mood disorder and comparison healthy subjects groups.
Table S4. Thapsigargin-sensitive endoplasmic reticulum-calcium (Ca2+) release in Ca2+ free medium in bipolar I disorder (BD-I) patients and comparison healthy subjects.
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