Figure S1. Reference genes stability analysis.

Figure S2. SP4 and SP1 protein levels are reduced in postmortem cerebellum and also SP4 mRNA and protein levels in postmortem prefrontal cortex from bipolar disorder subjects.

Figure S3. SP4 protein stability is regulated by depolarization.

Figure S4. Inhibition of calcium influx in cerebellar organotypic cultures decreased SP4 protein levels.

Figure S5. SP4 levels are restored upon proteasome inhibition.

Figure S6. Lithium increases SP1 protein levels in depolarizing conditions.

Figure S7. SP1 and SP4 levels are not altered in cerebellum or prefrontal cortex from suicide subjects compared to controls from the Brain Tissue Collection of the University of Basque Country.

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