Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study
Article first published online: 20 JUL 2012
© 2012 John Wiley and Sons A/S
Volume 14, Issue 6, pages 607–617, September 2012
How to Cite
Shi, X.-F., Kondo, D. G., Sung, Y.-H., Hellem, T. L., Fiedler, K. K., Jeong, E.-K., Huber, R. S. and Renshaw, P. F. (2012), Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study. Bipolar Disorders, 14: 607–617. doi: 10.1111/j.1399-5618.2012.01040.x
- Issue published online: 3 SEP 2012
- Article first published online: 20 JUL 2012
- Received 30 August 2011, revised and accepted for publication 15 May 2012
- bipolar disorder;
Shi X-F, Kondo DG, Sung Y-H, Hellem TL, Fiedler KK, Jeong E-K, Huber RS, Renshaw PF. Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study. Bipolar Disord 2012: 14: 607–617. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.
Objectives: To compare the concentrations of high-energy phosphorus metabolites associated with mitochondrial function in the frontal lobe of depressed adolescents with bipolar disorder (BD) and healthy controls (HC).
Methods: We used in vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) at 3 Tesla to measure phosphocreatine (PCr), beta-nucleoside triphosphate (β-NTP), inorganic phosphate (Pi), and other neurometabolites in the frontal lobe of eight unmedicated and six medicated adolescents with bipolar depression and 24 adolescent HCs.
Results: Analysis of covariance, including age as a covariate, revealed differences in PCr (p = 0.037), Pi (p = 0.017), and PCr/Pi (p = 0.002) between participant groups. Percentage neurochemical differences were calculated with respect to mean metabolite concentrations in the HC group. Post-hoc Tukey–Kramer analysis showed that unmedicated BD participants had decreased Pi compared with both HC (17%; p = 0.038) and medicated BD (24%; p = 0.022). The unmedicated BD group had increased PCr compared with medicated BD (11%; p = 0.032). The PCr/Pi ratio was increased in unmedicated BD compared with HC (24%; p = 0.013) and with medicated BD (39%; p = 0.002). No differences in β-NTP or pH were observed.
Conclusions: Our results support the view that frontal lobe mitochondrial function is altered in adolescent BD and may have implications for the use of Pi as a biomarker. These findings join volumetric studies of the amygdala, and proton MRS studies of n-acetyl aspartate in pointing to potential differences in neurobiology between pediatric and adult BD.