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Cardiovascular effects of vecuronium, atracurium, pancuronium, metocurine and RGH-420 1 in dogs
Article first published online: 30 DEC 2008
DOI: 10.1111/j.1399-6576.1989.tb02912.x
© 1989 Acta Anaesthesiologica Scandinavica Fonden
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How to Cite
Hackett, G. H., Jantzen, J.-P. A. H. and Earnshaw, G. (1989), Cardiovascular effects of vecuronium, atracurium, pancuronium, metocurine and RGH-420 1 in dogs. Acta Anaesthesiologica Scandinavica, 33: 298–303. doi: 10.1111/j.1399-6576.1989.tb02912.x
Publication History
- Issue published online: 30 DEC 2008
- Article first published online: 30 DEC 2008
- Received 5 December 1987, accepted for publication 5 December 1988
- Abstract
- References
- Cited By
Keywords:
- Neuromuscular relaxants: atracurium;
- metocurine;
- pancuronium;
- RGH-4201;
- vecuronium;
- neuromuscular relaxants: hemodynamic effects
The effect on the cardiovascular haemodynamic status of five neuromuscular blocking drugs, RGH-4201, vecuronium, atracurium, pancuronium and metocurine, was studied in five conditioned foxhounds anaesthetised with fentanyl. Changes in heart rate, mean arterial blood pressure, central venous pressure, mean pulmonary artery pressure, pulmonary capillary wedge pressure, and cardiac output were recorded at 2, 5, 10, 20 and 30 min after administration of the drugs. From these, stroke volume, systemic vascular resistance and pulmonary vascular resistance were calculated. Administration of RGH-4201 was followed by a pronounced increase in heart rate, accompanied by an increase in cardiac output and a decrease in systemic and pulmonary vascular resistance. Metocurine and pancuronium resulted in a decrease of right and left filling pressures and systemic-/pulmonary vascular resistance. Changes after atracurium, vecuronium and metocurine were minimal. It is concluded that RGH-4201 causes major alterations in the cardiovascular haemodynamic status in dogs anaesthetised with fentanyl when compared to vecuronium, atracurium, metocurine and pancuronium. With respect to cardiovascular stability, atracurium and vecuronium offer advantages.