Dose-dependent suppression of the neutrophil respiratory burst by lidocaine

Authors

  • P. M. Hyvönen,

    Corresponding author
    1. Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland
      Department of Pharmacology and Toxicology University of Kuopio P.O. Box 1627 FIN-70211 Kuopio Finland
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  • M. J. Kowolik

    1. Department of Oral Biology and Periodontology, Indiana University Dental School, Indianapolis, USA
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Department of Pharmacology and Toxicology University of Kuopio P.O. Box 1627 FIN-70211 Kuopio Finland

Abstract

Background: Oxygen radical production is thought to be fundamental to the pathogenesis of post-ischaemic reperfusion injury which is routinely managed with lidocaine. Attention has, therefore, focused on the suppression of the neutrophil respiratory burst with a therapeutic endpoint. The widest application of lidocaine remains in local analgesia.

Methods: A standard chemiluminescence technique was used to assess the human neutrophil leukocyte response to increasing doses of lidocaine in the presence or absence of particulate hydroxyapatite.

Results: No reduction of oxygen radical production was seen at the drug concentration of 1 mg/ml. A clear, concentration-dependent inhibition was seen at 2 mg/ml, 3 mg/ml, 4 mg/ml and 8 mg/ml concentrations. These drug concentrations may be reached at or near the site of injection in local anaesthetic use.

Conclusion: Lidocaine showed profound anti-inflammatory action in this experimental system. Controlled studies in the clinical setting would identify the optimal analgesic and anti-inflammatory dosage, whilst preserving host defence without compromising tissue repair.

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