Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children
Article first published online: 20 SEP 2006
2006 Acta Anaesthesiol Scand
Acta Anaesthesiologica Scandinavica
Volume 50, Issue 9, pages 1161–1164, October 2006
How to Cite
Lee, J., Oh, Y., Kim, C., Kim, S., Park, H. and Kim, H. (2006), Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children. Acta Anaesthesiologica Scandinavica, 50: 1161–1164. doi: 10.1111/j.1399-6576.2006.01134.x
- Issue published online: 20 SEP 2006
- Article first published online: 20 SEP 2006
- Accepted for publication 27 June 2006
- airway irritation;
Background: Airway irritation is a major drawback of desflurane anesthesia. This study was designed to evaluate the effect of intravenous fentanyl given before thiopental induction on airway irritation caused by a stepwise increase in desflurane in children.
Methods: Eighty children (2–8 years) were enrolled in a randomized, double-blind study. Forty received saline and 40 received 2 μg/kg of fentanyl intravenously; this was followed by thiopental sodium 5 mg/kg in both groups. Patients were assistant-ventilated with desflurane 1%, which was then increased by 1% every six breaths up to 10%. During this period, cough, secretion, excitation and apnea were graded and the desflurane concentration at which airway irritation symptoms first occurred was recorded. The results were analyzed using Pearson’s chi-squared test.
Results: The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2.5% vs. 42.5%; secretion, 27.5% vs. 82.5%; excitation, 10% vs. 82.5%; apnea, 20% vs. 65%; P < 0.05). The mean expired desflurane concentration at which the first airway irritation symptom occurred was greater with fentanyl than with saline (7.3% vs. 5.5%, P < 0.05).
Conclusions: Intravenous fentanyl in children reduces airway complications caused by desflurane.