Presented in part at the 28th Congress of the Scandinavian Society for Anesthesia and Intensive Care, 29 June to 3 July 2005, Reykjavik, Iceland.
Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia
Article first published online: 20 MAY 2008
© 2008 The Authors. Journal compilation © 2008 The Acta Anaesthesiologica Scandinavica Foundation
Acta Anaesthesiologica Scandinavica
Volume 52, Issue 7, pages 959–968, August 2008
How to Cite
CHEW, M. S., JOHANSSON, A., ANDERSON, C., ERSSON, A. and TØNNESEN, E. (2008), Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia. Acta Anaesthesiologica Scandinavica, 52: 959–968. doi: 10.1111/j.1399-6576.2008.01603.x
- Issue published online: 9 JUL 2008
- Article first published online: 20 MAY 2008
- Accepted for publication 23 November 2007
- myocardial dysfunction;
- energy metabolism;
Background: Myocardial dysfunction occurs commonly in septic shock. It is not known whether this is due to local ischaemia and metabolic disturbances. Our hypothesis was that endotoxaemic myocardial dysfunction may be associated with interstitial ischaemic and metabolic changes, measured using interstitial microdialysis (MD).
Methods: Eighteen pigs were randomized to control (n=6) or endotoxin infusion (n=12). MD catheters were inserted into the myocardium for measurement of interstitial glucose, pyruvate and lactate concentrations. Plasma glucose and lactate concentrations and systemic haemodynamic parameters were measured simultaneously.
Results: Compared with the control group, the endotoxaemic animals had significantly decreased left ventricular stroke work and venous oxygen saturation (SvO2), and increased mean pulmonary artery pressure and plasma lactate. In the endotoxaemic group, decreases in interstitial glucose were observed, occurring simultaneously with increases in interstitial pruvate. Interstitial lactate : pyruvate ratios decreased with time in all animals.
Conclusions: Despite severe systemic and pulmonary haemodynamic changes, interstitial MD measurements revealed no evidence of anaerobic metabolism in the myocardium of endotoxaemic pigs. There were, however, changes in glucose and pyruvate concentrations, suggesting local energy metabolic disturbances.