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Use of an endotoxin adsorber in the treatment of severe abdominal sepsis

Authors

  • V. V. KULABUKHOV

    1. Department of Anesthesiology and Resuscitation, Purulent-Septic Surgery Clinic of National Medical Surgery Center N. Pirogov, Moscow, Russia
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Address:
Vladimir V. Kulabukhov
Scientific Medical Surgery Center N. Pirogov
Str. N. Pervomayskaya 70
Moscow
105 203 Russia
e-mail: Vkulabukhov@gmail.com

Abstract

Methods for lipopolysaccharide (LPS) (endotoxin) reduction have been proposed as one way to improve the treatment of Gram-negative sepsis. Here we present a case with severe Gram-negative sepsis, treated with a novel device for LPS adsorption (Alteco® LPS Adsorber, Alteco Medical AB, Lund, Sweden). After LPS adsorption, the level of LPS in the patient's bloodsteam was almost eliminated: from 1.44 EU/ml before treatment to 0.03 EU/ml post treatment). The procalcitonin level and inflammatory cytokines were concurrently reduced. Also, an obvious improvement in the status of the patient's hemodynamics was seen. Forty-five days after treatment the patient is still alive. In conclusion, LPS adsorption may represent a significant improvement in the treatment of Gram-negative sepsis and further studies are planned.

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