Effect of magnesium sulfate on extubation time and acute pain in coronary artery bypass surgery
Article first published online: 17 OCT 2008
© 2008 The Authors. Journal compilation © 2008 The Acta Anaesthesiologica Scandinavica Foundation
Acta Anaesthesiologica Scandinavica
Volume 52, Issue 10, pages 1348–1352, November 2008
How to Cite
FERASATKISH, R., DABBAGH, A., ALAVI, M., MOLLASADEGHI, G., HYDARPUR, E., MOGHADAM, A. A., FARITUS, Z. S. and TOTONCHI, M. Z. (2008), Effect of magnesium sulfate on extubation time and acute pain in coronary artery bypass surgery. Acta Anaesthesiologica Scandinavica, 52: 1348–1352. doi: 10.1111/j.1399-6576.2008.01783.x
- Issue published online: 17 OCT 2008
- Article first published online: 17 OCT 2008
- Accepted for publication 17 July 2008
Background: Post-operative pain control is one of the greatest concerns for both physicians and patients. In this study, the effect of magnesium sulfate (MgSO4) solution infusion on post-operative pain scores and extubation time in patients undergoing elective coronary artery bypass graft (CABG) surgeries was assessed.
Methods: In a double-blind, randomized, placebo-controlled clinical trial, 218 patients scheduled for elective CABG were selected and randomly assigned to two groups. After matching inclusion and exclusion criteria for the patients, intravenous MgSO4 was administered intraoperatively for one group and placebo to the second group. Except for this, all the cases were similar regarding anesthesia and surgery.
Results: The MgSO4 patients were extubated sooner compared with the placebo group. Pain scores reported by the group who received MgSO4 were less at the 6th, 12th, 18th and 24th hours after the operation; also, they needed less morphine sulfate during this period.
Conclusion: The results demonstrated a significantly shortened post-operative time for extubation and reduced acute post-operative pain scores by intravenous MgSO4 infusion during elective CABG surgery.