The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest
Version of Record online: 12 JUL 2010
© 2010 The Authors. Journal compilation © 2010 The Acta Anaesthesiologica Scandinavica Foundation
Acta Anaesthesiologica Scandinavica
Volume 54, Issue 8, pages 1027–1035, September 2010
How to Cite
TORGERSEN, C., SCHMITTINGER, C. A., TAKALA, J., JAKOB, S. M. and DÜNSER, M. W. (2010), The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest. Acta Anaesthesiologica Scandinavica, 54: 1027–1035. doi: 10.1111/j.1399-6576.2010.02273.x
- Issue online: 3 AUG 2010
- Version of Record online: 12 JUL 2010
- Accepted for publication 13 June 2010
Background: Currently, few data exist on the association between post-cardiac arrest hemodynamic function and outcome. In this explorative, retrospective analysis, the association between hemodynamic variables during the first 24 h after intensive care unit admission and functional outcome at day 28 was evaluated in 153 normothermic comatose patients following a cardiac arrest.
Methods: Medical records of a multidisciplinary intensive care unit were reviewed for comatose patients (Glasgow Coma Scale ≤9) admitted to the intensive care unit after successful resuscitation from an in- or an out-of-hospital cardiac arrest. The hourly variable time integral of hemodynamic variables during the first 24 h after admission was calculated. At day 28, outcome was assessed as favorable or adverse based on a Cerebral Performance Category of 1–2 and 3–5, respectively. Bi- and multivariate regression models adjusted for relevant confounding variables were used to evaluate the association between hemodynamic variables and functional outcome.
Results: One hundred and fifty-three normothermic comatose patients were admitted after a cardiac arrest, of whom 64 (42%) experienced a favorable outcome. Neither in the adjusted bivariate models (r2, 0.61–0.78) nor in the adjusted multivariate model (r2, 0.62–0.73) was the hourly variable time integral of any hemodynamic variable during the first 24 h after intensive care unit admission associated with functional patient outcome at day 28 in all patients as well as in patients after an in- or an out-of-hospital cardiac arrest.
Conclusion: Commonly measured hemodynamic variables during the first 24 h following intensive care unit admission due to a cardiac arrest do not appear to be associated with the functional outcome at day 28.