This study was performed at Seoul National University Bundang Hospital, 300 Gumidong Seongnam-si Bundang-gu Kyeonggi-do 463-707, Korea.
Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study
Article first published online: 8 NOV 2010
© 2010 The Authors. Journal compilation © 2010 The Acta Anaesthesiologica Scandinavica Foundation
Acta Anaesthesiologica Scandinavica
Volume 55, Issue 1, pages 104–109, January 2011
How to Cite
YOON, H. I., KIM, J.-H., LEE, J.-H., PARK, S., LEE, C.-T., HWANG, J.-Y., NAHM, S. F. and HAN, S. (2011), Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study. Acta Anaesthesiologica Scandinavica, 55: 104–109. doi: 10.1111/j.1399-6576.2010.02336.x
- Issue published online: 3 DEC 2010
- Article first published online: 8 NOV 2010
- Accepted for publication 15 September 2010
Background: Propofol is an excellent sedative agent for use in patients undergoing bronchoscopy. The addition of an opioid to propofol can be advantageous because of the antitussive effect of the opioid and the possible improvement in sedation quality. However, it may increase the risk of hypoxaemia. To investigate the effect of the addition of alfentanil to propofol, we performed a prospective study to compare propofol-only sedation with propofol–alfentanil combination sedation in patients undergoing bronchoscopy.
Methods: Patients were randomly assigned either to the propofol-only (group P, n=32) or to the propofol–alfentanil combination group (group PA, n=32). The average peripheral oxygen saturation (SpO2) and the lowest SpO2 during the sedation were compared. Patient and bronchoscopist satisfaction as well as the degree of coughing were compared using a 100 mm visual analogue scale, where 0 indicated the least and 100 indicated the most satisfied.
Results: Group P had the higher average SpO2 (%) during the procedure than group PA (97.8±1.6 and 96.4±1.1, P<0.01) as well as the lowest SpO2 (%) (95.4±2.7and 94.0±2.4, P<0.05). Patient satisfaction (92.2±13.5 and 92.3±18.2), bronchoscopist satisfaction (76.6±18.1 and 72.8±19.1), and degree of cough (73.4±22.7 and 72.2±18.5; group P and group PA, respectively) were not different between the groups.
Conclusions: The combination of propofol and alfentanil resulted in a greater respiratory depression than propofol alone; furthermore, the addition of an opioid did not improve the quality of sedation. In conclusion, we do not recommend sedation with propofol and alfentanil during bronchoscopy.