Evidence for epistasis: reply to Trouve et al.
Version of Record online: 10 SEP 2004
Journal of Evolutionary Biology
Volume 17, Issue 6, pages 1402–1404, November 2004
How to Cite
Ebert, D., Salathé, P. and Kawecki, T. J. (2004), Evidence for epistasis: reply to Trouve et al. Journal of Evolutionary Biology, 17: 1402–1404. doi: 10.1111/j.1420-9101.2004.00803.x
- Issue online: 10 SEP 2004
- Version of Record online: 10 SEP 2004
- Received 11 April 2004; revised 30 June 2004; accepted 1 July 2004
- synergistic epistasis;
- hybrid vigour;
Salathé and Ebert (2003, J. Evol. Biol. 16: 976–985) have shown that the mean logarithmic fitness of Daphnia magna clones declined faster than linearly with increasing inbreeding coefficient F. They interpreted this result as evidence for synergistic epistasis. Trouve et al. (2004, J. Evol. Biol., doi: 10.1111/j.1420-9101.2004.00755.x) suggested that hybrid vigour could be an alternative explanation for this finding. We use a population genetic model to support the original claim that the marked deviation from linearity cannot be explained without epistasis. We further argue that the relevant reference population is the metapopulation and not the subpopulation. Taken together, we believe that synergistic epistasis between recessive deleterious alleles segregating in the D. magna metapopulation is the most likely explanation for the finding of Salathé and Ebert.