Distribution of HBsAg Subtypes in the World
Article first published online: 5 MAR 2009
© 1983 S. Karger AG, Basel
Volume 44, Issue 4, pages 197–211, April 1983
How to Cite
Couroucé-Pauty, A.-M., Plançon, A. and Soulier, J.P. (1983), Distribution of HBsAg Subtypes in the World. Vox Sanguinis, 44: 197–211. doi: 10.1111/j.1423-0410.1983.tb01885.x
- Issue published online: 5 MAR 2009
- Article first published online: 5 MAR 2009
- Received: July 1, 1982; Accepted: July 30, 1982
Abstract. HBsAg subtyping was performed in 5,337 sera from chronic carriers who originated from 54 different countries of the 5 continents. Nine subtypes were defined: ayw1, ayw2, ayw3, ayw4, ayr, adw2, adw4, adr q- and adr q+. The repartition of these subtypes, according to the country of origin of the carriers, enhances the previous results and supplies new data: ayw1 is prevalent only in Vietnam (51%); ayw2 in Mediterranean countries (73%); ayw3 in Greece and Yugoslavia (54%) along with ayw2 (41%); ayw4 in West Africa (82%) and Central Africa (42%) along with ayw2; ayr was only found in Vietnam (3.4%); adw2 is prevalent in North and Central Europe (70%), East and South Africa (95%), India (55%), along with ayw3 (35%) in northern South America (74%), and in the Antilles (82%); adw4 is widespread in French Polynesia (45%) — with a 100% frequency in the Marquesas archipelago — as well as in Argentina (42%); adr q- was found only in Oceania: French Polynesia (34%) with a 69% frequency in the Australes, New Caledonia (3 out of 3 HBsAg carriers); adr q+ is the prevalent subtype in South-East Asia if we exclude Vietnam (61%).
These results show that a precise geographical distribution of HBsAg subtypes needs more than ‘four main subtypes’ generally used. Enlarging from 4 subtypes to 9 is a requirement for valuable epidemiologic studies, as well as for the specification of anti-HBs antibodies produced by hybrids or induced by synthetic peptide. The geographical distribution of these 9 HBsAg subtypes and the serological relationship between some determinants suggest a genetic recombination of viral DNA.