Supported in part by USPHS grants CA 29894 (PWA) HD12487, CA18470 and CA10815 (BBK and DS) from the NIH.
Red Cell Antigens P (Globoside) and Luke: Identification by Monoclonal Antibodies Defining the Murine Stage-Specific Embryonic Antigens -3 and -4 (SSEA-3 and SSEA-4)1
Version of Record online: 5 MAR 2009
© 1986 S. Karger AG, Basel
Volume 51, Issue 1, pages 53–56, July 1986
How to Cite
Tippett, P., Andrews, P. W., Knowles, B. B., Solter, D. and Goodfellow, P. N. (1986), Red Cell Antigens P (Globoside) and Luke: Identification by Monoclonal Antibodies Defining the Murine Stage-Specific Embryonic Antigens -3 and -4 (SSEA-3 and SSEA-4). Vox Sanguinis, 51: 53–56. doi: 10.1111/j.1423-0410.1986.tb00209.x
- Issue online: 5 MAR 2009
- Version of Record online: 5 MAR 2009
- Received: September 9, 1985; Accepted: October 18, 1985
Abstract. Two globoseries antigens (antigens borne on carbohydrate chains containing globoside), SSEA-3 and SSEA-4, were found on the red cells of the majority of people, but were absent from cells of rare p and Pk individuals which lack globoside. In addition, SSEA-4 was absent from red cells of Luke(-) individuals which nevertheless express the P antigen (globoside) and SSEA-3. The name LKE is proposed for the red cell antigen detected by the Luke serum and by MC813–70, the monoclonal antibody defining SSEA-4. Among the LKE+ individuals, a few showed relatively weak expression of the antigen and were grouped separately as a LKE weak (LKEw) phenotype. Using MC813–70, the frequencies of the 3 phenotypes LKE+, LKEw and LKE- in an English donor population are 0.914, 0.072 and 0.014, respectively.