Thrombotic thrombocytopenic purpura and pregnancy: a review of ten cases


Correspondence: M. Pujol, Centre de Transfusió i Banc de Teixits, Hospital Universitari Germans Trias i Pujot, Cra. del Canyet, s/n 08916, Badalona, Spain.


Background and Objectives  A series of women with pregnancy-associated thrombotic thrombocytopenic purpura, is presented. This study will focus on the relationship between thrombotic thrombocytopenic purpura and pregnancy and on maternal and neonatal outcomes.

Materials and Methods  Among forty-six consecutive patients with thrombotic thrombocytopenic purpura, nine pregnant patients were identified.

Results  Seven patients presented an acute single episode associated with pregnancy and two patients had a chronic relapsing form of the disease. None of these two patients were diagnosed during pregnancy or in the postpartum period. There was one maternal death. Fetal mortality was 33%.

Conclusions  The recurrence is rare in women who had the prior episode related to pregnancy. The risk of death for these patients seems not higher than that of the remaining patients in the series. Preterm delivery and intrauterine fetal death were frequent complications of these pregnancies.