Leucocyte antibodies in blood donors and a look back on recipients of their blood components
Article first published online: 23 JAN 2007
Volume 92, Issue 3, pages 247–249, April 2007
How to Cite
Maślanka, K., Michur, H., Żupańska, B., Uhrynowska, M. and Nowak, J. (2007), Leucocyte antibodies in blood donors and a look back on recipients of their blood components. Vox Sanguinis, 92: 247–249. doi: 10.1111/j.1423-0410.2007.00890.x
- Issue published online: 19 FEB 2007
- Article first published online: 23 JAN 2007
- Received: 15 November 2006, revised 12 December 2006, accepted 12 December 2006
- female blood donors;
- HLA antibodies;
- leucocyte antibodies;
Background and Aim The role of leucocyte antibodies in donors is poorly understood in pathogenesis of transfusion-related acute lung injury (TRALI). We examined antibodies in donors and traced recipients transfused with their blood components.
Material and Methods Antibodies were examined in 1043 donors by five methods, look back performed in 26 recipients.
Results Anti-human leucocyte antigen detected by enzyme-linked immunosorbent assay in 9·8% women but none in men. Specificities identified using FlowPRA, antibodies detected after several months. TRALI reported in one recipient from immunized donor. In 11 of 26 recipients without TRALI, cognate antigens were identified.
Conclusion Detection of antibodies in donors cannot predict TRALI, even in recipients with cognate antigen(s).