Fibrinogen concentrates for bleeding trauma patients: what is the evidence?
Article first published online: 3 MAY 2011
© 2011 The Author(s). Vox Sanguinis © 2011 International Society of Blood Transfusion
Volume 101, Issue 3, pages 185–190, October 2011
How to Cite
Meyer, M. A. S., Ostrowski, S. R., Windeløv, N. A. and Johansson, P. I. (2011), Fibrinogen concentrates for bleeding trauma patients: what is the evidence?. Vox Sanguinis, 101: 185–190. doi: 10.1111/j.1423-0410.2011.01478.x
- Issue published online: 16 SEP 2011
- Article first published online: 3 MAY 2011
- Received: 6 December 2010, revised 21 January 2011, accepted 22 January 2011, published online 3 May 2011
- fibrinogen concentrate;
Introduction A balanced transfusion of red blood cells, fresh frozen plasma and platelets are recommended for massively bleeding trauma patients. Fibrinogen concentrates could potentially lessen or replace the need for fresh frozen plasma and/or platelet transfusions.
Objective To provide a review of the literature covering the application of fibrinogen concentrates in trauma care.
Methods PubMed and Cochrane database search, ‘fibrinogen’ and (‘concentrate’ or ‘trauma’), not ‘congenital’, 10 years.
Results Only four papers were identified. None were randomized controlled trials. The main conclusion of these papers was that administration of fibrinogen sometimes together with prothrombin complex concentrate might improve haemostasis in trauma patients resuscitated with synthetic colloids.
Conclusion Evidence for the use of fibrinogen concentrate to trauma patients with massive bleeding is lacking. Well-designed prospective, randomized, double-blinded studies evaluating the effect of fibrinogen concentrate, as the only intervention, are urgently needed.