Both authors contributed equally to this work.
Pathogen inactivation technology applied to a blood component collected from an asymptomatic carrier of Leishmania infantum: a case report
Version of Record online: 19 JUN 2012
© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion
Volume 103, Issue 4, pages 356–358, November 2012
How to Cite
Jimenez-Marco, T., Fisa, R., Riera, C., Girona-Llobera, E., Sedeño, M., Saura, A., Iniesta, L., Guillen, C. and Muncunill, J. (2012), Pathogen inactivation technology applied to a blood component collected from an asymptomatic carrier of Leishmania infantum: a case report. Vox Sanguinis, 103: 356–358. doi: 10.1111/j.1423-0410.2012.01622.x
- Issue online: 18 OCT 2012
- Version of Record online: 19 JUN 2012
- Received: 19 December 2011 revised 11 May 2012 accepted 12 May 2012
- malaria and protozoal infections;
- pathogen inactivation.
Asymptomatic Leishmania infections have been the main cause of transfusion transmission in endemic areas. Polymerase chain reaction has been used to detect L. infantum DNA in the peripheral blood of asymptomatic Leishmania carriers. In our region, the prevalence of asymptomatic L. infantum infection in donors is markedly high (5·9% of donors studied). We investigated the ability of pathogen inactivation technology, using amotosalen and UVA illumination, to eliminate L. infantum in a blood component collected from an asymptomatic L. infantum infected donor. This is the first report of the INTERCEPT system being used to eliminate a parasite from a component collected from a donor.