Platelet transfusions in haematology patients: are we using them appropriately?
Article first published online: 9 JUL 2012
© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion
Volume 103, Issue 4, pages 284–293, November 2012
How to Cite
Estcourt, L. J., Birchall, J., Lowe, D., Grant-Casey, J., Rowley, M. and Murphy, M. F. (2012), Platelet transfusions in haematology patients: are we using them appropriately?. Vox Sanguinis, 103: 284–293. doi: 10.1111/j.1423-0410.2012.01627.x
- Issue published online: 18 OCT 2012
- Article first published online: 9 JUL 2012
- Received: 31 January 2012, revised 3 May 2012, accepted 9 May 2012
- transfusion medicine
Background and Objectives A large proportion of all platelet components are given to haematology patients. As there are risks associated with their transfusion, costs associated with production, and shortages may occur, it is important that their use is appropriate.
Study Design and Methods The study was split into two parts, a survey to assess local practice guidelines and an assessment of platelet usage. A total of 123 hospitals completed the survey and 168 hospitals submitted data of 40 haematology patients over a 3-month period.
Results The organizational survey found that 36% of hospitals routinely give prophylactic platelet transfusions to patients with long-term bone-marrow failure. Also, a significant minority of hospitals administer platelet transfusions if the platelet count is below a certain threshold prior to performing a bone-marrow aspirate (11%) or a bone-marrow aspirate and trephine (23%); both of these are contrary to UK platelet transfusion guidelines. Data were collected on a total of 3402 patients, of which 3296 cases were eligible for analysis. They received approximately 46% of all platelet components issued to participating hospitals in England during the study period. The majority (69%) of platelet transfusions were prophylactic; of these only 33% were given when the platelet count was ≤10 × 109/l. Using an algorithm, based on current UK guidelines, 60% of prophylactic transfusions were appropriate, 6% could not be assessed and 34% were inappropriate. A total of 10% of all prophylactic transfusions were double the standard adult dose.
Conclusions There is considerable potential for decreased use of platelet transfusions with a consequent improvement in their appropriate use and cost reduction.