The clinical benefit of blood transfusion: a hypothetical experiment based on a nationwide survey of severe maternal morbidity
Article first published online: 13 OCT 2012
© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion
Volume 104, Issue 3, pages 234–239, April 2013
How to Cite
Hendriks, J., Zwart, J. J., Briët, E., Brand, A. and van Roosmalen, J. (2013), The clinical benefit of blood transfusion: a hypothetical experiment based on a nationwide survey of severe maternal morbidity. Vox Sanguinis, 104: 234–239. doi: 10.1111/j.1423-0410.2012.01654.x
- Issue published online: 21 MAR 2013
- Article first published online: 13 OCT 2012
- Received: 15 March 2012, revised 20 August 2012, accepted 20 August 2012
- blood transfusion;
- maternal mortality ratio;
Background It is beyond doubt that blood transfusion services have added to the decline in maternal mortality in high-resource countries. To quantify the clinical benefit of red blood cell (RBC) transfusion in obstetric care, we performed a hypothetical experimental study using data from a prospective nationwide cohort of women giving birth in the Netherlands.
Study Design and Methods Data were abstracted from a nationwide cohort study on severe maternal morbidity, including obstetric haemorrhage requiring 4 or more units of RBC, to obtain an observed and a hypothetical control group consisting of the same women. In the hypothetical control group, we simulated a situation where RBC transfusion was unavailable and estimated how many of these women would have died in that situation. A questionnaire survey asked experts in major (obstetric) haemorrhage to choose a critical minimal number of RBC transfusions at which a woman with obstetric haemorrhage would have died if RBC transfusion was not available. Maternal mortality rate per 100 000 maternities [maternal mortality ratios (MMR)] and relative risk were calculated for the observed and hypothetical group.
Results The observed MMR was 13 per 100 000 maternities. According to 47 responding experts, the median number of RBC units without which a woman would have most probably died was nine, resulting in a hypothetical MMR of 87 per 100 000 maternities (relative risk 6·5; 95% confidence interval 4·2–10·0).
Conclusions It can be expected that unavailability of RBC transfusion in obstetric care increases the risk of maternal death 6.5-fold. Blood transfusion thus largely contributes to the decline of MMR and would also be an important pillar of improving quality of care in resource-poor settings.