*Present address: Department of Cell Biology, The Scripps Research Institute, CB163, La Jolla, CA 92037, U.S.A.
Ribonucleoprotein remodeling during RNA localization
Article first published online: 23 MAR 2007
Volume 75, Issue 6, pages 507–518, July 2007
How to Cite
Lewis, R. A. and Mowry, K. L. (2007), Ribonucleoprotein remodeling during RNA localization. Differentiation, 75: 507–518. doi: 10.1111/j.1432-0436.2007.00159.x
- Issue published online: 23 MAR 2007
- Article first published online: 23 MAR 2007
- Received September 6, 2006; accepted in revised form November 16, 2006
- RNA remodeling;
- RNA localization;
- RNP complex;
- cell polarity;
- post-transcriptional control
Abstract Cytoplasmic RNA localization is a means to create polarity by restricting protein expression to a discrete subcellular location. RNA localization is a multistep process that begins with the recognition of cis-acting sequences within the RNA by specific trans-factors, and RNAs are localized in ribonucleoprotein (RNP) complexes that contain both the RNA and numerous protein components. Components of the localization machinery transport the RNP complex, usually in a translationally repressed state, to a distinct subcellular region, resulting in spatially restricted gene expression. Recent efforts to identify both the cis- and trans-factors required for RNA localization have elucidated RNA–protein interactions that are remodeled during localization.