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Ribonucleoprotein remodeling during RNA localization

Authors

  • Raymond A. Lewis,

    1. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, U.S.A.
      Tel: +1 401 863 3636
      Fax: +1 401 863 1201
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    • *Present address: Department of Cell Biology, The Scripps Research Institute, CB163, La Jolla, CA 92037, U.S.A.

  • Kimberly L. Mowry

    Corresponding author
    1. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, U.S.A.
      Tel: +1 401 863 3636
      Fax: +1 401 863 1201
      ✉ E-mail: Kimberly_Mowry@Brown.edu
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✉ E-mail: Kimberly_Mowry@Brown.edu

Abstract

Abstract Cytoplasmic RNA localization is a means to create polarity by restricting protein expression to a discrete subcellular location. RNA localization is a multistep process that begins with the recognition of cis-acting sequences within the RNA by specific trans-factors, and RNAs are localized in ribonucleoprotein (RNP) complexes that contain both the RNA and numerous protein components. Components of the localization machinery transport the RNP complex, usually in a translationally repressed state, to a distinct subcellular region, resulting in spatially restricted gene expression. Recent efforts to identify both the cis- and trans-factors required for RNA localization have elucidated RNA–protein interactions that are remodeled during localization.

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