Lipid Composition of Human Malignant Melanoma Tumors at Various Levels of Malignant Growth

Authors

  • Jacques PORTOUKALIAN,

    1. Laboratoire de Physiologie Générale et Comparee, Université Claude-Bernard,43 Boulevard du 11 Novembre 1918, F-69621 Villeurbanne, France
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  • Georges ZWINGELSTEIN,

    Corresponding author
    1. Laboratoire de Physiologie Générale et Comparee, Université Claude-Bernard,43 Boulevard du 11 Novembre 1918, F-69621 Villeurbanne, France
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  • Jean-François DORÉ

    1. Laboratoiré d'Immunologie et de Cancérologie Expérimentale, Centre Léon Bérard, F-69373 Lyon-Cedex-2, France
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To whom correspondence should be addressed.

Abstract

The lipid pattern of thirteen human melanoma tumors from various tissues were investigated. In seven of the tumors, an estimate was given about the proportion of malignant melanocytes to the total cell population, and a reverse correlation was determined between the proportion of malignant cells in these tumors and their neutral lipid content. The phospholipids did not show any modification, nor did the cholesterol in the cancerous tissues. The ganglioside pattern was found to be similar in all analyzed samples, with GM3, GM2 and GD3 as major components, although no correlation was found between the malignant level and the ganglioside content of the tumors.

Abbreviations
For sialic acid-containing glycosphinglipids

the symbols proposed by Svennerholm [14] are used. GM3, N-acetylneuraminylgalactosylglucosylceramide

GM2

N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide

GM1

galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide

GD3

N-acetylneuraminyl-N-acetylneuraminylgalactosylglucosylceramide

GD1a

N-acetylneuraminylgalactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide

GD2

N-acetylgalactosaminyl-(N-acetylneuraminyl-N-acetylneuraminyl)-galactosylglucosylceramide

Enzyme
 

Neuraminidase (EC 3.2.1.18)

Ancillary