Respectfully dedicated to Dr Fritz Lipmann, New York, on the occasion of his 80th birthday.
A Rare Genetically Determined Variant of Pseudocholinesterase in two German Families with High Plasma Enzyme Activity
Article first published online: 28 JUN 2008
European Journal of Biochemistry
Volume 99, Issue 1, pages 65–69, August 1979
How to Cite
DELBRÜCK, A. and HENKEL, E. (1979), A Rare Genetically Determined Variant of Pseudocholinesterase in two German Families with High Plasma Enzyme Activity. European Journal of Biochemistry, 99: 65–69. doi: 10.1111/j.1432-1033.1979.tb13231.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- (Received February 22/May 28, 1979)
Activity of pseudocholinesterase (acylcholine-acyl-hydrolase) elevated up to four times has been detected in sera of members of two German families. The catalytic concentrations of the pseudocholinesterase of the afflicted members of both families (male and female) varied between 4800 U/l and 10200 U/l (acetylthiocholine iodide substrate). The pseudocholinesterase of the propositi exhibits isoenzyme separation patterns in polyacrylamide electrophoresis as well as in electrofocussing which are different from those of pseudocholinesterase from normal persons. No differences could be seen as regards the Km of substrates or the inhibition by dibucaine, fluoride or succinyldiocholine.