• 1
    Samuelsson, B., Dahlén, S.-E., Lindgren, J. Å., Rozer, C. A. & Serhan, C. N. (1987) Leukotrienes and lipoxins:structures, biosynthesis and biological effects, Science 237, 11711176.
  • 2
    Ohta, H., Ida, S., Mikami, B. & Mority, Y. (1986) Change in lipoxygenase components of rice seedlings during germination, Plant Cell Physiol. 27, 911918.
  • 3
    Yamamoto, A., Fuji, Y., Asumoto, K. & Mistsuda, H. (1990) Product specificity of rice germ lipoxygenase, Lipids 15, 15.
  • 4
    Zimmerman, D. C. & Feng, P. (1978) Characterization of a prostaglandin-like metabolite of linolenic acid produced by a flaxseed extract, Lipids 13, 313316.
  • 5
    Vick, B. A. & Zimmerman, D. C. (1983) The biosynthesis of jasmonic acid: a physiological role for plant lipoxygenases, Biochem. Biophys. Res. Commun. 111, 470477.
  • 6
    Feiters, M. C., Boelens, H., Veldink, G. A., Vliegenthart, J. F. G., Navaratnam, S., Allen, J. C., Nolting, H.-F. & Hermes, C. (1990) X-ray absorption spectroscopic studies on iron in soybean lipoxygenase: a model for mammalian lipoxygenases, Recl. Trav. Chim. Pays-Bas 109, 133146.
  • 7
    Shibata, D., Steczko, J., Dixon, J. E., Hermodson, M., Yazdanparast, R. & Axelrod, B. (1987) Primary structure of soybean lipoxygenase-1, J. Biol. Chem. 262, 1008010085.
  • 8
    Chan, H. W.-S. (1973) Soya-bean lipoxygenase: an iron-containing dioxygenase, Biochim. Biophys. Acta 327, 3235.
  • 9
    De Groot, J. J. M. C., Veldink, G. A., Vliegenthart, J. F. G., Boldingh, J., Wever, R. & Van Gelder, B. F. (1975) Demonstration by EPR spectroscopy of the functional role of iron in soybean lipoxygenase-1, Biochim. Biophys. Acta 377, 7179.
  • 10
    Slappendel, S., Malmström, B. G., Petersson, L., Ehrenberg, A., Veldink, G. A. & Vliegenthart, J. F. G. (1982) On the spin and valence state of iron in native soybean lipoxygenase-1, Biochem. Biophys. Res. Commun. 108, 673677.
  • 11
    Veldink, G. A., Boelens, H., Maccarrone, M., van der Lecq, F., Vliegenthart, J. F. G., Paz, M. A., Flückiger, R. & Gallop, P. M. (1990) Soybean lipoxygenase-1 is not a quinoprotein, FEBS Lett. 270, 135138.
  • 12
    Navaratnam, S., Feiters, M. C., Al-Hakim, M., Allen, J. C., Veldink, G. A. & Vliegenthart, J. F. G. (1988) Iron environment in soybean lipoxygenase-1, Biochim. Biophys. Acta 956, 7076.
  • 13
    Dunham, W. R., Carroll, R. T., Thompson, J. F., Sands, R. H. & Funk, M. O. Jr (1990) The initial characterization of the iron environment in lipoxygenase by Mössbauer spectroscopy, Eur. J. Biochem. 190, 611617.
  • 14
    Shibata, D., Stezko, J., Dixon, J. E., Andrews, P. C., Hermodson, M., Yazdanparast, R. & Axelrod, B. (1988) Primary structure of soybean lipoxygenase-2, J. Biol. Chem. 263, 68166821.
  • 15
    Nguyen, T., Falgueyret, J.-P., Abramovitz, M. & Riendeau, D. (1991) Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase, J. Biol. Chem. 266, 2205722062.
  • 16
    Van der Heijdt, L. M., Veldink, G. A., Vliegenthart, J. F. G., Feiters, M. C., Navaratnam, S., Nolting, H.-F. & Hermes, C. (1991) EXAFS of soybean lipoxygenase-1, in X-ray absorption fine structure (Hasnain, S. S., ed.) pp. 125127, Ellis Horwood, Chichester .
  • 17
    Slappendel, S. (1982) Magnetic and spectroscopic studies on soybean lipoxygenase-1, Ph. D. Thesis, Utrecht University.
  • 18
    Verhagen, J., Veldink, G. A., Egmond, M. R., Vliegenthart, J. F. G., Boldingh, J. & Van der Star, J. (1978) Steady-state kinetics of the anaerobic reaction of soybean lipoxygenase-1 with linoleic acid and 13-l-hydroperoxylinoleic acid, Biochim. Biophys. Acta 529, 369379.
  • 19
    Petersson, L., Slappendel, S., Feiters, M. C. & Vliegenthart, J. F. G. (1987) Magnetic susceptibility studies on yellow and anaerobically substrate-treated yellow soybean lipoxygenase-1, Biochim. Biophys. Acta 913, 228237.
  • 20
    Hermes, C., Gilberg, E. & Koch, M. G. I. (1984) A double-focusing EXAFS beam line, data acquisition and evaluation system for biological applications, Nucl. Instrum. Methods 222, 207214.
  • 21
    Pettifer, R. F. & Hermes, C. (1986) An X-ray monochromator suitable for studying biological systems, J. Phys. 12-47-C8, 127132.
  • 22
    Pettifer, R. F. & Hermes, C. (1985) Absolute energy calibration of X-ray radiation from synchrotron sources, J. Appl. Crystall. 18, 404412.
  • 23
    Van der Hock, M. J., Werner, W., Van Zuylen, P., Dobson, B. R., Hasnain, S. S., Worgan, J. S. & Luickx, G. (1986) A slitless double crystal monochromator for EXAFS and XANES measurements, Nucl. Instrum. Methods A2-46, 380384.
  • 24
    Nolting, H.-F. (1988) Cobalt in biologisch wichtigen Metallkoordinationszentren, Ph. D. Thesis, University of Münster.
  • 25
    Gurman, S. J., Binsted, N. & Ross, I. (1984) A rapid, exact, curved-wave theory for EXAFS calculations, J. phys. C. Solid State Phys. 17, 143151.
  • 26
    Gurman, S. J., Binsted, N. & Ross, I. (1986) A rapid, exact, curved-wave theory for EXAFS calculations: II. The multiplescattering contributions, J. Phys. C. Solid State Phys. 19, 18451861.
  • 27
    Bordas, J., Dobson, G. G., Grewe, H., Koch, M. H. J., Krebs, B. & Randell, J. (1983) A comparative assessment of the zinc-protein corrdination in 2Zn-insulin as determined by X-ray absorption fine structure (EXAFS) and X-ray crystallography, Proc. R. Soc. Lond. B 219, 2139.
  • 28
    Sayers, D. E., Stern, E. A. & Lytle, F. W. (1971) New technique for investigating noncrystalline structures. Fourier analysis of the extended X-ray absorption fine structure, Phys. Rev. Lett. 27, 12041207.
  • 29
    Shulman, R. G., Yafet, Y., Eisenberger, P. & Blumberg, W. E. (1976) Observation and interpretation of X-ray edges in iron compounds and proteins, Proc. Natl Acad. Sci. USA 73, 13841388.
  • 30
    Roe, A. L., Schneider, D. J., Mayer, R. J., Pryz, J. W., Widom, J. & Que, L. Jr (1984) X-ray absorption spectroscopy of iron-tyrosinate proteins, J. Am. Chem. Soc. 106, 16761681.
  • 31
    Srivastava, U. C. & Nigam, H. L. (1973) X-ray absorption edge spectrometry (XAES) as applied to coordination chemistry, Coord. Chem. Rev. 9, 275310.
  • 32
    Nolting, H.-F. (1985) Röntgenabsorptionsspektroskopische Untersuchungen an der K-Absorptionskante einfacher Eisenverbindungen mit Synchrotronstrahlung, M. D. Thesis, University of Münster.
  • 33
    Zhang, Y., Gebhard, M. S. & Solomon, E. I. (1991) Spectroscopic studies of the non-heme ferric active site in soybean lipoxygenase – magnetic circular dichroism as a probe of electronic and geometric structure – ligand-field origin of zero-field splitting, J. Am. Chem. Soc. 131, 51625175.
  • 34
    Nelson, M. J. (1988) Evidence for water coordinated to the active-site iron in soybean lipoxygenase-1, J. Am. Chem. Soc. 110, 29852986.
  • 35
    Lindley, P. F. (1991) EXAFS and crystallographic studies of metallo-proteins, in X-ray absorption fine structure (Hasnain, S. S., ed.) pp. 115121, Ellis Horwood, Chichester .
  • 36
    Blackburn, N. J., Hasnain, S. S., Binsted, N., Diakun, G. P., Garner, C. D. & Knowles, P. F. (1984) An extended X-ray-absorption-fine-structure study on bovine erythrocyte superoxide dismutase in aqueous solution. Direct evidence for three-coordinate copper(I) in reduced enzyme. Biochem. J. 219, 985990.
  • 37
    Bianconi, A., Giovanelli, A., Ascone, I., Alema, S., Durham, P. & Fasella, F. P. (1983) XANES of calmodulin: differences and homologies between calcium-modulated proteins, in EXAFS and near-edge structure (Bianconi, A., Incoccia, L. & Stipcich, S., eds) pp. 355357, Springer-Verlag, Heidelberg .
  • 38
    Strange, R. W., Hasnain, S. S., Blackburn, N. J. & Knowles, P. F. (1986) Multiple scattering in the EXAFS of imidazole-containing complexes, J. Phys. 12-47-C8, 593596.
  • 39
    Pettifer, R. F., Foulis, D. L. & Hermes, C. (1986) Multiple scattering calculations for biological catalysts, J. Phys. 12-47-C8, 545550.
  • 40
    Hasnain, S. S. & Strange, R. W. (1990) Recent advances in XAFS data analysis, in Synchrotron radiation and biophysics (Hasnain, S. S., ed.) pp. 104121, Ellis Horwood, Chichester .
  • 41
    Nelson, M. J. (1987) The nitric oxide complex of ferrous soybean lipoxygenase-1. Substrate, pH, and ethanol effects on the active site iron, J. Biol. Chem. 262, 1213712142.
  • 42
    Slappendel, S., Aasa, R., Malmström, B. G., Verhagen, J., Veldink, G. A. & Vliegenthart, J. F. G. (1982) Faactors affecting the line-shape of the EPR signal of high-spin Fe(III) in soybean lipoxygenase-1, Biochim. Biophys. Acta 708, 259265.
  • 43
    De Groot, J. J. M. C., Garsen, G. J., Vliegenthart, J. F. G. & Boldingh, J. (1973) The detection of linoleic acid radicals in the anaerobic reaction of lipoxygenase, Biochim. Biophys. Acta 326, 279284.
  • 44
    Yue, K. T., Lee, M., Zheng, J. & Callender, R. (1991) The determination of the PKa of histindine residues in proteins by Raman difference spectroscopy, Biochim. Biophys. Acta 1078, 296302.
  • 45
    Bertini, I., Luchinat, C. & Monnanni, R. (1985) Evidence of the breaking of the copper-imidazolate bridge in copper/cobaltsubstituted superoxide dismutase upon reduction of the copper(II) centers, J. Am. Chem. Soc. 107, 21782179.
  • 46
    Fee, J. A. & DiCorletti, P. E. (1973) Oxidation/reduction properties of bovine erythrocyte superoxide dismutase, Biochemistry 12, 48934899.
  • 47
    True, A. E., Orville, A. M., Pearce, L. L., Lipscomb, J. D. & Que, L. Jr (1990) An EXAFES study of the interaction of substrate with the ferric active site of protocatechuate 3,4-dioxygenase, Biochemistry 29, 1084710854.
  • 48
    Funk, M. O., Jr, Carroll, R. T., Thompson, J. F., Sands, R. H. & Dunham, W. R. (1990) Role of iron in lipoxygenase catalysis, J. Am. Chem. Soc. 112, 53755376.