The molecular mechanism of erythropoietin action

Authors

  • Mark J. KOURY,

    Corresponding author
    1. Division of Hematology, Vanderbilt University School of Medicine and Veteran's Administration Medical Center, Nashville, USA
      Correspondence to M. J. Koury, Room C-3101, Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232–2287, USA
      Fax: + 1 615 343 4589.
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  • Maurice C. BONDURANT

    1. Division of Hematology, Vanderbilt University School of Medicine and Veteran's Administration Medical Center, Nashville, USA
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Correspondence to M. J. Koury, Room C-3101, Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232–2287, USA
Fax: + 1 615 343 4589.

Abbreviations
BFU-E

burst-forming-unit erythroid

CFU-E

colony-forming-unit erythroid

CHO

Chinese hamster ovary

EPO

erythropoietin

FVA cells

splenic erythroblasts from mice infected with Friend leukemia virus (anemia-inducing strain)

GATA-1

transcription factor that binds DNA sequence GATA in erythroid cells

GM-CSF

granulocyte-macrophage colony-stimulating factor

HCD cells

an erythropoietin-dependent murine erythroleukemia cell line

rh-EPO

recombinant human erythropoietin

SFFVP

Friend spleen focus-forming virus (polycythemia-inducing)

uh-EPO

urinary human erythropoietin

IL

interleukin