Note. Dedicated to Professor Britton Chance on the occasion of his 80th birthday on July on 24, 1993.
Strategies of antioxidant defense
Article first published online: 3 MAR 2005
European Journal of Biochemistry
Volume 215, Issue 2, pages 213–219, July 1993
How to Cite
SIES, H. (1993), Strategies of antioxidant defense. European Journal of Biochemistry, 215: 213–219. doi: 10.1111/j.1432-1033.1993.tb18025.x
- Issue published online: 3 MAR 2005
- Article first published online: 3 MAR 2005
- (Received February 10/March 16, 1993) – EJB 93 0076/0
Cellular protection against the deleterious effects of reactive oxidants generated in aerobic metabolism, called oxidative stress, is organized at multiple levels. Defense strategies include three levels of protection; prevention, interception, and repair. Regulation of the antioxidant capacity includes the maintenance of adequate levels of antioxidant and the localization of antioxidant compounds and enzymes. Short-term and long-term adaptation and cell specialisation in these functions are new areas of interest. Control over the activity of prooxidant enzymes, such as NADPH oxidase and NO synthases, is crucial. Synthetic antioxidants mimic biological strategies.