1. Top of page
  2. Abstract
  3. References

The most relevant allergen of the storage mite Lepidoglyphus destructor (Lep d I) has been characterized. Lep d I is a monomer protein of 13273 Da. The primary structure of Lep d I was determined by N-terminal Edman degradation and partially confirmed by cDNA sequencing. Sequence polymorphism was observed at six positions, with non-conservative substitutions in three of them. No potential N-glycosylation site was revealed by peptide sequencing, The 125-residue sequence of Lep d I shows approximately 40% identity (including the six cysteines) with the overlapping regions of group II allergens from the genus Dermatophagoides, which, however, do not share common allergenic epitopes with Lep d I.


radio allergosorbent test


rapid amplification of cDNA 3′ end


Trypsin (EC


chymotrypsin (EC


endoproteinase Glu-C (EC


endoproteinase Asp-N (EC


proline-specific endopeptidase (EC


  1. Top of page
  2. Abstract
  3. References
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