SEARCH

SEARCH BY CITATION

References

  • 1
    Cross, D. A. E., Alessi, D. R., Vandenheede, J. R., McDowell, H. E., Hundal, H. S. & Cohen, P. (1994) The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin. Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf, Biochem J. 303, 2126.
  • 2
    Kapeller, R. & Cantley, L. C. (1994) Phosphatidylinositol 3-kinase, Bioessays 8, 565576.
  • 3
    Monfar, M., Lemon, K. P., Crammer, T. C., Cheatham, L., Chung, J. K., Vlahos, C. J. & Blenis, J. (1995) Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP, Mol. Cell Biol. 15, 336337.
  • 4
    Shepherd, P. R., Navé, B. T. & Siddle, K. (1995) Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes. Evidence for the involvement of phosphoinositide 3-kinase and p70 ribo-somal protein36 kinase, Biochem. J. 305, 2528.
  • 5
    Yamamoto-Honda, R., Tobe, K., Kaburagi, Y., Ueki, K., Asai, S., Yachi, M., Shirouzu, M., Yodoi, J., Akanuma, Y., Yokoyama, S., Yazaki, Y. & Kadowaki, T. (1995) Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I–Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21(ras), J. Biol. Chem. 270, 27292734.
  • 6
    Welsh, G. I., Foulstone, E. J., Young, S. W., Tavaré, J. M. & Proud, C. G. (1994) Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen activated protein kinase, Biochem. J. 303, 1520.
  • 7
    Sheperd, P. R., Reaves, B. J. & Davidson, H. W. (1996) Phosphoinositide 3-kinases and membrane traffic, Trends Cell Biol. 6, 9297.
  • 8
    Quon, M. J., Chen, H., Ing, B. L., Liu, M. L., Zarnowski, M. J., Yonezawa, K., Kasuga, M., Cushman, S. W. & Taylor, S. I. (1995) Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells, Mol. Cell. Biol. 15, 54035411.
  • 9
    Clarke, J. F., Young, P. W., Yonezawa, K., Kasuga, M. & Holman, G. D. (1994) Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-Ll cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin, Biochem. J. 300, 631635.
  • 10
    Clague, M. J., Thorpe, C. & Jones, A. T. (1995) Phosphatidylinositol 3-kinase regulation of fluid phase endocytosis, FEBS Lett. 367, 272274.
  • 11
    Li, G. P., D'Souza-Schorey, C., Barbieri, M. A., Roberts, R. L., Klippel, A., Williams, L. T. & Stahl, P. D. (1995) Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5, Proc. Natl Acad. Sci. USA 92, 1020710211.
  • 12
    Jones, A. T. & Clague, M. J. (1995) Phosphatidylinositol 3-kinase activity is required for early endosome fusion, Biochem. J. 311, 3134.
  • 13
    Brown, W. J., De Wald, D. B., Emr, S. D., Plunter, H. & Balch, W. E. (1995) Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells, J. Cell Biol. 130, 781796.
  • 14
    Davidson, H. W. (1995) Wortmannin causes mistargeting of proca-thepsin D. The involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes, J. Cell Biol. 130, 797805.
  • 15
    Cardone, M. & Mostov, K. (1995) Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor, FEBS Lett. 376, 7476.
  • 16
    Schu, P. V., Takegawa, K., Fry, M. J., Stack, J. H., Waterfield, M. D. & Emr, S. D. (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting, Science 260, 8891.
  • 17
    Stack, J. H. & Emr, S. D. (1994) VPS34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PtdIns 3-kinase activities, J. Biol. Chem. 269, 3155231562.
  • 18
    Seglen, P. O. & Gordon, P. B. (1984) Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes, J. Cell Biol. 99, 435444.
  • 19
    Seglen, P. O. & Gordon, P. B. (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes, Proc. Natl Acad. Sci. USA 79, 18891892.
  • 20
    Groen, A. K., Sips, H. J., Vervoorn, R. C. & Tager, J. M. (1982) Intracellular compartmentation and control of alanine metabolism in rat liver parenchymal cells, Eur. J. Biochem. 122, 8793.
  • 21
    Leverve, X. M., Caro, L. H. P., Plomp, P. J. A. M. & Meijer, A. J. (1987) Control of proteolysis in perifused hepatocytes. FEBS Lett. 219, 455458.
  • 22
    Meijer, A. J., Gustafson, L. A., Luiken, J. J. F. P., Blommaart, P. J. E., Caro, L. H. P., Van Woerkom, G. M., Spronk, C. & Boon, L. (1993) Cell swelling and the sensitivity of autophagic proteolysis to inhibition by amino acids in isolated rat hepatocytes, Eur. J. Biochem. 215, 449454.
  • 23
    Williamson, J. R. & Corkey, B. E. (1969) Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods, Methods Enzymol. 13, 434513.
  • 24
    Luiken, J. J. F. P., Aerts, J. M. F. G. & Meijer, A. J. (1996) The role of the intralysosomal pH in the control of autophagic proteolytic flux in rat hepatocytes, Eur. J. Biochem. 235, 564573.
  • 25
    Meijer, A. J., Lof, C., Ramos, I. C. & Verhoeven, A. J. (1985) Control of ureagenesis, Eur. J. Biochem. 148, 189196.
  • 26
    Schworer, C. M. & Mortimore, G. E. (1979) Glucagon induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids, Proc. Natl Acad. Sci. USA 76, 31693173.
  • 27
    Seglen, P. O., Gordon, P. B. & Poli, A. (1980) Amino acid inhibition of the autophagicllysosomal pathway of protein degradation in isolated rat hepatocytes, Biochim. Biophys. Acta 630, 103118.
  • 28
    Seglen, P. O., Grinde, B. & Solheim, A. I. (1979) Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin, Eur. J. Biochem. 95, 215225.
  • 29
    Caro, L. H. P., Plomp, P. J. A. M., Wolvetang, E. J., Kerkhof, C. & Meijer, A. J. (1988) 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism, Eur. J. Biochem. 175, 325329.
  • 30
    Plomp, P. J. A. M., Wolvetang, E. J., Groen, A. K., Meijer, A. J., Gordon, P. B. & Seglen, P. O. (1987) Energy dependence of autophagic protein degradation in isolated rat hepatocytes, Eur. J. Biochem. 164, 197203.
  • 31
    Høyvik, H., Gordon, P. B. & Seglen, P. O. (1986) Use of a hydroly-sable probe. [14C]lactose to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway, Exp. Cell. Res. 166, 114.
  • 32
    Powis, G., Bonjouklian, R., Berggren, M. M., Gallegos, A., Abraham, R., Ashendel, C., Zalkow, L., Matter, W. F., Dodge, J., Grindey, G. & Vlahos, C. J. (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 54, 24192423.
  • 33
    Vlahos, C. J., Matter, W. F., Kui, K. Y. & Brown, R. F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-benzopyran-4-one (LY294002), J. Biol. Chem. 269, 52415248.
  • 34
    Krause, U., Rider, M. H. & Hue, L. (1996) Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-coA carboxylase in isolated rat hepatocytes, J. Biol. Chem. 271, 1666816673.
  • 35
    Blommaart, E. F. C., Luiken, J. J. F. P., Blommaart, P. J. E., Van Woerkom, G. M. & Meijer, A. J. (1995) Phosphorylation of ribo-somal protein S6 is inhibitory for autophagic proteolysis in isolated rat hepatocytes, J. Biol. Chem. 270, 23202326.
  • 36
    Nakanishi, S., Catt, K. J. & Balla, T. (1995) A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids, Proc. Natl Acad. Sci. USA 92, 53175322.
  • 37
    Downing, G. J., Kim, S., Nakanishi, S., Catt, K. J. & Balla, T. (1996) Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type 111 phosphatidylinositol kinases, Biochemistry 35, 35873594.
  • 38
    Hendil, K. B., Lauridsen, A. B. & Seglen, P. O. (1990) Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serumhmino acid deprivation and inhibited by 3-meth-yladenine, Biochem. J. 272, 577581.
  • 39
    Punnonen, E. L., Marjomaki, V. S. & Reunanen, H. (1994) 3- Methyladenine inhibits transport from late endosomes to lyso-somes in cultured rat and mouse fibroblasts, Eur. J. Cell Biol. 65, 1425.
  • 40
    Reaves, B. J., Bright, N. A., Mullock, B. M. & Luzio, J. P. (1996) The effect of wortmannin on the localisation of lysosomal type 1 integral membrane glycoproteins suggests a role for phosphoino-sitide 3-kinase activity in regulating membrane traffic late in the endocytic pathway, J. Cell Sci. 109, 749762.
  • 41
    Kelly, K. L. & Ruderman, N. B. (1993) Insulin stimulated phospha-tidylinositol 3-kinase: association with a 185-kDa tyrosine-phos-phorylated protein (IRS-I) and localization in a low density membrane vesicle, J. Biol. Chem. 268, 43914398.
  • 42
    Martys, L. J., Wjasow, C., Gangi, D. M., Kielian, M. C., McGraw, T. E. & Jonathan, M. B. (1996) Wortmannin sensitive trafficking pathways in chinese hamster ovary cells–Differential effects on endocytosis and lysosomal sorting, J. Biol. Chem. 271, 1095310962.
  • 43
    Kelly, K. L., Ruderman, N. B. & Chen, K. S. (1992) Phosphatidyli-nositol-3-kinase in isolated rat adipocytes– Activation by insulin and subcellular distribution, J. Biol. Chem. 267, 34233428.
  • 44
    Dunn, W. A. (1990) Studies on the mechanisms of autophagy: formation of the autophagic vacuole, J. Cell Biol. 110, 19231933.