Note. This Minireview will be reprinted in EJB Reviews 1997 which will be available in April 1998.
The 2-His-1-Carboxylate Facial Triad — An Emerging Structural Motif in Mononuclear Non-Heme Iron(II) Enzymes
Article first published online: 23 JUN 2004
European Journal of Biochemistry
Volume 250, Issue 3, pages 625–629, December 1997
How to Cite
Hegg, E. L. and Jr, L. Q. (1997), The 2-His-1-Carboxylate Facial Triad — An Emerging Structural Motif in Mononuclear Non-Heme Iron(II) Enzymes. European Journal of Biochemistry, 250: 625–629. doi: 10.1111/j.1432-1033.1997.t01-1-00625.x
- Issue published online: 23 JUN 2004
- Article first published online: 23 JUN 2004
- (Received 4 July 1997) – EJB 97 0947/0
- 2-His-1-carboxylate facial triad;
A 2-His-1-carboxylate facial triad is a common feature of the active sites in a number of mononuclear non-heme iron(II) enzymes. This structural motif was established crystallographically for five different classes of enzymes and inferred from sequence similarity for two other classes. The 2-His-1-carboxylate facial triad anchors the iron in the active site and at the same time maintains three additional cis-oriented sites. These sites can be used to bind other endogenous ligands or exogenous ligands such as substrate and/or O2, giving the metal center great flexibility to use different mechanistic strategies to perform a variety of chemical transformations.