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Keywords:

  • Cyclosporine;
  • Cynomolgus monkey;
  • Kidney transplantation;
  • Neoral;
  • Pharmacokinetics

Abstract

  1. Top of page
  2. Abstract
  3. References

Abstract In cynomolgus and rhesus monkeys, the dose-normalized exposure of cyclosporine administered orally as microemulsion preconcen-trate (Neoral) was lower than that upon intramuscular administration. For oral administration, mean values (± SD) of Cmax, 24-h area-under-the curve (AUC) and 24-h trough level, all normalized for a 1 mg/kg dose, were 20 ± 9 ng kg/mg ml, 210 ± 70 ng h kg/mg ml and 2.6 ± 0.9 ng kg/mg ml, respectively. For intramuscular administration, levels were about 5.5-fold, 9-fold and 22-fold higher. Based on phar-macokinetic data, the efficacy of oral cyclosporine treatment (without any other immunosuppressant) was evaluated in life-supporting cynomolgus monkey kidney allotransplantation. Rejection-free kidney allograft survival could be achieved using oral cyclosporine monotherapy with average 24-h trough concentrations above 100 ng/ml during maintenance treatment. Typically, daily oral doses of 100 mg/kg-150 mg/kg during the first two weeks post-transplantation, followed by daily 30 mg/kg-100 mg/kg dose levels during subsequent maintenance can result in long-term allograft survival, with 24-h average trough levels in individual animals during maintenance between 110 ng/ml and 700 ng/ml.

Abbreviations
AUC

Area-under-the-curve

BPRC

Biomedical Primate Research Centre, Rijswijk, The Netherlands

MLR

Mixed lymphocyte reactivity

References

  1. Top of page
  2. Abstract
  3. References
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