The influence of obesity on short- and long-term graft and patient survival after renal transplantation

  1. Jeroen Aalten1,
  2. Maarten H. Christiaans2,
  3. Hans De Fijter3,
  4. Ronald Hené4,
  5. Jaap Homan van der Heijde5,
  6. Joke Roodnat6,
  7. Janto Surachno7,
  8. Andries Hoitsma1

Article first published online: 31 AUG 2006

DOI: 10.1111/j.1432-2277.2006.00367.x

Issue

Transplant International

Transplant International

Volume 19, Issue 11, pages 901–907, November 2006

Additional Information

How to Cite

Aalten, J., Christiaans, M. H., De Fijter, H., Hené, R., Homan van der Heijde, J., Roodnat, J., Surachno, J. and Hoitsma, A. (2006), The influence of obesity on short- and long-term graft and patient survival after renal transplantation. Transplant International, 19: 901–907. doi: 10.1111/j.1432-2277.2006.00367.x

Author Information

  1. 1

     Department of Nephrology, University Medical Center St Radboud, Nijmegen, The Netherlands

  2. 2

     Department of Nephrology, University Hospital Maastricht, Maastricht, The Netherlands

  3. 3

     Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands

  4. 4

     Department of Nephrology, University Medical Center, Utrecht, The Netherlands

  5. 5

     Department of Nephrology, Groningen University Medical Center, Groningen, The Netherlands

  6. 6

     Department of Nephrology, Erasmus University Medical Center, Rotterdam, The Netherlands

  7. 7

     Department of Nephrology, Academic Medical Center, Amsterdam, The Netherlands

*Jeroen Aalten, Department of Nephrology, 464, University Medical Center St Radboud, Postbus 9101, 6500 HB Nijmegen, The Netherlands. Tel.: 003 124 361 4761; fax: 003 124 354 0022; e-mail: j.aalten@AIG.umcn.nl

Publication History

  1. Issue published online: 31 AUG 2006
  2. Article first published online: 31 AUG 2006
  3. Received: 6 February 2006 Revision requested: 16 February 2006 Accepted: 14 June 2006

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Keywords:

  • graft survival;
  • obesity;
  • patient survival;
  • renal transplantation

Summary

To determine short- and long-term patient and graft survival in obese [body mass index (BMI) ≥ 30 kg/m2] and nonobese (BMI < 30 kg/m2) renal transplant patients we retrospectively analyzed our national-database. Patients 18 years or older receiving a primary transplant after 1993 were included. A total of 1871 patients were included in the nonobese group and 196 in the obese group. In the obese group there were significantly more females (52% vs. 38.6%, P < 0.01) and patients were significantly older [52 years (43–59) vs. 48 years (37–58); P < 0.05]. Patient survival and graft survival were significantly decreased in obese renal transplant recipients (1 and 5 year patient survival were respectively 94% vs. 97% and 81% vs. 89%, P < 0.01; 1 and 5 year graft survival were respectively 86% vs. 92% and 71% vs. 80%, P < 0.01). Initial BMI was an independent predictor for patient death and graft failure. This large retrospective study shows that both graft and patient survival are significantly lower in obese renal transplant recipients.

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