These authors contributed equally to this study.
Correlation of the CD4+CD25high T-regulatory cells in recipients and their corresponding donors to acute GVHD
Article first published online: 20 FEB 2007
Volume 20, Issue 5, pages 440–446, May 2007
How to Cite
Zhai, Z., Sun, Z., Li, Q., Zhang, A., Liu, H., Xu, J., Xu, X., Geng, L., Harris, D., Hu, S. and Wang, Y. (2007), Correlation of the CD4+CD25high T-regulatory cells in recipients and their corresponding donors to acute GVHD. Transplant International, 20: 440–446. doi: 10.1111/j.1432-2277.2007.00462.x
- Issue published online: 20 FEB 2007
- Article first published online: 20 FEB 2007
- Received: 21 July 2006 Revision requested: 20 August 2006 Accepted: 9 January 2007
- acute graft-versus-host disease;
- allogeneic hematopoietic stem cell transplant;
- CD4+CD25high T cells;
Graft-versus-host disease continues to be a major life-threatening complication after allogeneic hematopoietic stem cells transplantation (aHSCT). The relationship of acute GVHD (aGVHD) with the levels of peripheral CD4+CD25high T cells in patients after aHSCT and in their corresponding donors is not fully investigated. We examined the levels of CD4+CD25high T cells in patients after aHSCT and in their corresponding donors, and analyzed the relationship of CD4+CD25high T cells to the incidence and prognosis of aGVHD. The recipients with normal or high CD4+CD25high T cells (three of eight, 37.5%) had no or mild aGVHD (grade I), and all survived during the follow-up period. In striking contrast, the recipients with lower or no CD4+CD25high T cells suffered from greater than grade II aGVHD (four of four, 100%), and all died within 1-year post-aHSCT. Moreover, the number of CD4+CD25high T cells in recipients correlated significantly with that of their corresponding donors. The CD4+CD25high T cells from the recipients and their corresponding donors expressed high levels of Foxp3, and effectively suppressed the proliferation of CD4+CD25− responder T cells. This study suggests that human Treg cells may play an important role in aGVHD, as has been seen in murine models. The levels of peripheral CD4+CD25high T cells in recipients and donors could be helpful for predicting of the onset and outcome of aGVHD.