Conflict of Interest The authors of this manuscript have no conflicts of interest to disclose.
No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients
Article first published online: 22 MAR 2012
© 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation
Special Issue: Special Focus - Antibody-Mediated Rejection
Volume 25, Issue 6, pages 646–651, June 2012
How to Cite
Beirão, M., Matos, E., Beirão, I., Pinho-Costa, P. and Torres, P. (2012), No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients. Transplant International, 25: 646–651. doi: 10.1111/j.1432-2277.2012.01467.x
- Issue published online: 15 MAY 2012
- Article first published online: 22 MAR 2012
- Received: 1 December 2011 Revision requested: 15 January 2012 Accepted: 27 February 2012 Published online: 22 March 2012
- familial amyloidotic polyneuropathy;
- liver transplantation;
In many transplantation centers domino liver transplantation is an established procedure, increasing the number of available liver grafts. Increasingly, grafts from familial amyloidotic polyneuropathy (FAP) patients are used. Ocular involvement is a well known manifestation of FAP, and can be vision-threatening. The aim of this study was to evaluate the risk of development of familial amyloidotic polyneuropathy ocular manifestations in domino liver recipients. Forty-four cirrhotic patients submitted to liver transplantation were studied, with an average of 6 years of follow up after the procedure. Twenty two patients had received a liver from a FAP donor (Group 1) and 22 had received a liver from a non-FAP cadaveric donor (Group 2). Both groups were similar for mean age and gender. Routine ophthalmological examinations with particular attention to amyloid deposition in the anterior segment and vitreous, peripheral retina state, lacrimal functions tests (Schirmer and tear break-up time) and pupillometry (dynamic and static) were performed. No statistically significant differences were observed in all studied ophthalmic parameters between the two groups. No FAP related ophthalmic manifestations were detected after 6 years of domino liver transplantation, but further prospective regular ophthalmological examinations are necessary to detect the eventual development of late ocular manifestations.