Serum leptin correlates in infertile oligozoospermic males

  1. S. Hanafy1,
  2. F. A. Halawa2,
  3. T. Mostafa3,
  4. N. W. Mikhael1,
  5. K. T. Khalil1

Article first published online: 14 AUG 2007

DOI: 10.1111/j.1439-0272.2007.00779.x

Issue

Andrologia

Andrologia

Volume 39, Issue 5, pages 177–180, October 2007

Additional Information

How to Cite

Hanafy, S., Halawa, F. A., Mostafa, T., Mikhael, N. W. and Khalil, K. T. (2007), Serum leptin correlates in infertile oligozoospermic males. Andrologia, 39: 177–180. doi: 10.1111/j.1439-0272.2007.00779.x

Author Information

  1. 1

     Dermatology & Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt;

  2. 2

     Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt;

  3. 3

     Andrology & Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

*Dr Taymour Mostafa, Andrology & Sexology Department, Faculty of Medicine, Cairo University, Cairo 11562, Egypt. Tel.: +20 10 515 0297; E-mail: taymour1155@link.net

Publication History

  1. Issue published online: 14 AUG 2007
  2. Article first published online: 14 AUG 2007
  3. Accepted: June 4, 2007

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Keywords:

  • Infertility;
  • leptin;
  • semen;
  • seminal plasma;
  • testosterone

Summary

Leptin is an adipocyte-secreted protein that participates in the regulation of energy homeostasis. Eighty men were investigated; fertile normozoospermia as a control (n = 30) and infertile oligozoospermia (n = 50). The patients underwent estimation of body weight (kg), height (cm), calculation of body mass index (BMI), semen analysis, serum leptin and testosterone hormones. Mean body weight was significantly higher in infertile oligozoospermia compared with controls. Mean height, BMI and serum testosterone levels showed nonsignificant differences between the two groups. Infertile oligozoospermia had significantly higher mean serum leptin level than controls (mean ± SD; 6.88 ± 8.65, 16.3 ± 13.98 ng ml−1, P < 0.01). Serum leptin demonstrated significant positive correlation with age, body weight, BMI and significant inverse correlation with serum testosterone. It had nonsignificant correlation with the height and sperm concentration. These results are suggestive of a link between the adipocyte derived hormone, leptin and male reproduction.

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