Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats

  1. A. S. Hill1,
  2. J. A. Werner2,
  3. Q. R. Rogers1,
  4. S. L. O'Neill2,
  5. M. M. Christopher2

Article first published online: 1 APR 2004

DOI: 10.1111/j.1439-0396.2003.00472.x

Issue

Journal of Animal Physiology and Animal Nutrition

Journal of Animal Physiology and Animal Nutrition

Volume 88, Issue 3-4, pages 150–156, April 2004

Additional Information

How to Cite

Hill, A. S., Werner, J. A., Rogers, Q. R., O'Neill, S. L. and Christopher, M. M. (2004), Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats. Journal of Animal Physiology and Animal Nutrition, 88: 150–156. doi: 10.1111/j.1439-0396.2003.00472.x

Author Information

  1. 1

    Departments of Molecular Biosciences Clinical Sciences

  2. 2

    Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA

*Author's address: Dr Ana Hill, College of Veterinary Medicine, 601 Vernon L. Tharp St, The Ohio State University, Columbus, OH 43210, USA, E-mail: hill.687@osu.edu

Publication History

  1. Issue published online: 1 APR 2004
  2. Article first published online: 1 APR 2004
  3. Receipt of Ms.: 05. 01. 2003 Accepted: 05. 08. 2003

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Summary

The antioxidant lipoic acid (LA) is administered to humans and pets. We described acute toxicity and maximum tolerated dose (MTD) of LA in cats. In progression, 10 healthy adult male cats received orally 60 (high), 30 (low), or 0 mg LA/kg (control). Serum enzyme activities and concentrations of bile acids, ammonia, amino acids (AA), LA and dihydrolipoic acid (DHLA) were measured, and tissues examined microscopically. Significant clinical toxicity with changes in ammonia and AA concentrations occurred in all high-dose cats. Oral LA produced hepatocellular toxicity and MTD was <30 mg/kg in cats.

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