Effects of diets supplemented with organic acids and nucleotides on growth, immune responses and digestive tract development in weaned pigs

  1. D. N. Lee1,
  2. S. R. Liu1,
  3. Y. T. Chen1,
  4. R. C. Wang1,
  5. S. Y. Lin2,
  6. C. F. Weng3

Article first published online: 19 JUN 2007

DOI: 10.1111/j.1439-0396.2007.00684.x

Issue

Journal of Animal Physiology and Animal Nutrition

Journal of Animal Physiology and Animal Nutrition

Volume 91, Issue 11-12, pages 508–518, December 2007

Additional Information

How to Cite

Lee, D. N., Liu, S. R., Chen, Y. T., Wang, R. C., Lin, S. Y. and Weng, C. F. (2007), Effects of diets supplemented with organic acids and nucleotides on growth, immune responses and digestive tract development in weaned pigs. Journal of Animal Physiology and Animal Nutrition, 91: 508–518. doi: 10.1111/j.1439-0396.2007.00684.x

Author Information

  1. 1

     Department of Animal Science, National Ilan University, Ilan, Taiwan

  2. 2

     Animal Technology Institute Taiwan, Chunan, Miaoli, Taiwan, and

  3. 3

     Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan

*Dr. C. F. Weng, Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan. Tel: +886 3 8633637; Fax: +886 3 8630255; E-mail: cfweng@mail.ndhu.edu.tw

Publication History

  1. Issue published online: 19 JUN 2007
  2. Article first published online: 19 JUN 2007
  3. Received: 20 June 2006; accepted: 16 November 2006

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (181K)

Keywords:

  • organic acids;
  • nucleotides;
  • weaned pigs;
  • gut-associated immune responses;
  • digestive enzyme

Summary

Sixty-eight (Experiment 1, 46 days feeding) and sixteen (Experiment 2, 21 days feeding) 21-days-old weaned pigs were allotted to four dietary treatments including control, 0.6% organic acids (OA), 0.1% nucleotides (NA) and 0.6% OA plus 0.1% NA for determining the dietary effects. In Experiment 1, OA enhanced peripheral blood mononuclear cells proliferation on day 28 and 46. The plasma immunoglobulin (Ig) A level was elevated by OA (p < 0.06) and NA (p < 0.07), respectively. In Experiment 2, NA increased plasma IgM level, and had an interactive effect with OA on ileal Peyer's patches and mesenteric lymph node lymphocyte proliferation, bile and plasma IgA levels, and jejunal crypt depth. NA elevated gastric pepsin and jejunal alkaline phosphatase activities, however, decreased ileal aminopeptidase N, sucrase or maltase activity. These results suggest that OA and NA have synergistically enhanced the gut-associated lymphocyte responses and NA modulates the digestive tract development of weaned pigs.

View Full Article (HTML) Get PDF (181K)