In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

  1. K. Kang1,
  2. K.-S. Wong1,
  3. C. Jayampath Seneviratne2,
  4. L. P. Samaranayake2,
  5. W.-P. Fong1,
  6. P. W.-K. Tsang1

Article first published online: 15 JUN 2009

DOI: 10.1111/j.1439-0507.2009.01747.x

Issue

Mycoses

Mycoses

Volume 53, Issue 6, pages 495–499, November 2010

Additional Information

How to Cite

Kang, K., Wong, K.-S., Jayampath Seneviratne, C., Samaranayake, L. P., Fong, W.-P. and Tsang, P. W.-K. (2010), In vitro synergistic effects of metergoline and antifungal agents against Candida krusei. Mycoses, 53: 495–499. doi: 10.1111/j.1439-0507.2009.01747.x

Author Information

  1. 1

    Department of Biochemistry (Science), The Chinese University of Hong Kong, Shatin, Hong Kong, China

  2. 2

    Faculty of Dentistry, The University of Hong Kong, Hong Kong, China

*Paul Wai-Kei Tsang, Department of Biochemistry (Science), The Chinese University of Hong Kong, Room 289, Science Centre South Block, Shatin, Hong Kong, China. Tel.: +852 3163 4359. Fax: +852 2603 7246. E-mail: paultsang@cuhk.edu.hk

Publication History

  1. Issue published online: 15 JUN 2009
  2. Article first published online: 15 JUN 2009
  3. Accepted for publication 11 May 2009

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Keywords:

  • Candida krusei;
  • metergoline;
  • synergism;
  • phospholipase

Summary

Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml−1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375–0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.

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