Conflict of interest: All authors declare no conflict of interests.
Regulation of Luteal Function and Corpus Luteum Regression in Cows: Hormonal Control, Immune Mechanisms and Intercellular Communication
Article first published online: 9 JUL 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Verlag
Reproduction in Domestic Animals
Special Issue: 16th International Congress on Animal Reproduction
Volume 43, Issue Supplement s2, pages 57–65, July 2008
How to Cite
Skarzynski, D., Ferreira-Dias, G. and Okuda, K. (2008), Regulation of Luteal Function and Corpus Luteum Regression in Cows: Hormonal Control, Immune Mechanisms and Intercellular Communication. Reproduction in Domestic Animals, 43: 57–65. doi: 10.1111/j.1439-0531.2008.01143.x
- Issue published online: 9 JUL 2008
- Article first published online: 9 JUL 2008
The main function of the corpus luteum (CL) is production of progesterone (P4). Adequate luteal function to secrete P4 is crucial for determining the physiological duration of the oestrous cycle and for achieving a successful pregnancy. The bovine CL grows very fast and regresses within a few days at luteolysis. Mechanisms controlling development and secretory function of the bovine CL may involve many factors that are produced both within and outside the CL. Some of these regulators seem to be prostaglandins (PGs), oxytocin, growth and adrenergic factors. Moreover, there is evidence that P4 acts within the CL as an autocrine or paracrine regulator. Each of these factors may act on the CL independently or may modify the actions of others. Although uterine PGF2α is known to be a principal luteolytic factor, its direct action on the CL is mediated by local factors: cytokines, endothelin-1, nitric oxide. The changes in ovarian blood flow have also been suggested to have some role in regulation of CL development, maintenance and regression.