Conflict of interest: The authors declare no conflict of interests.
Role of Cell Death Ligand and Receptor System on Regulation of Follicular Atresia in Pig Ovaries
Article first published online: 9 JUL 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Verlag
Reproduction in Domestic Animals
Special Issue: 16th International Congress on Animal Reproduction
Volume 43, Issue Supplement s2, pages 268–272, July 2008
How to Cite
Manabe, N., Matsuda-Minehata, F., Goto, Y., Maeda, A., Cheng, Y., Nakagawa, S., Inoue, N., Wongpanit, K., Jin, H., Gonda, H. and Li, J. (2008), Role of Cell Death Ligand and Receptor System on Regulation of Follicular Atresia in Pig Ovaries. Reproduction in Domestic Animals, 43: 268–272. doi: 10.1111/j.1439-0531.2008.01172.x
- Issue published online: 9 JUL 2008
- Article first published online: 9 JUL 2008
Several hundred thousand primordial follicles are present in the mammalian ovary, however, only a limited number develop to the pre-ovulatory stage, and then finally ovulate. The others, more than 99%, will be eliminated through a degenerative process called ‘atresia’. The endocrinological regulatory mechanisms involved in follicular development and atresia have been characterized to a large extent, but the precise temporal and molecular mechanisms involved in the regulation of these events have remained unknown. From many recent studies, it is suggested that the apoptosis in ovarian granulosa cells plays a crucial role in follicular atresia. Notably, death ligand–receptor interaction and subsequent intracellular signalling have been demonstrated to be the key mechanisms regulating granulosa cell apoptosis. In this review, we provide an overview of granulosa cell apoptosis regulated by death ligand–receptor signalling. The roles of death ligands and receptors [Fas ligand (FasL)–Fas, tumour necrosis factor (TNF)α–TNF receptor (TNFR), and TNFα-related apoptosis-inducing ligand (TRAIL)–TRAIL receptor (TRAILR)] and intracellular death-signal mediators [Fas-associated death domain protein (FADD), TNF receptor 1-associated death domain protein (TRADD), caspases, apoptotic protease-activating factor 1 (Apaf1), TNFR-associated factor 2 (TRAF2), and cellular FLICE-like inhibitory protein (cFLIP), etc.] in granulosa cells will be discussed.