Embryonic Stem Cells in Cattle


Author’s address (for correspondence): Marta Muñoz, Area de Genética y Reproducción, SERIDA, Camino de los Claveles 604, 33203 Gijón, Asturias, Spain. E-mail: mmunoz@serida.org


Because of the potential use of embryonic stem cells (ESC), especially for genetic modifications, there is great interest in establishing domestic animals-related ESCs. Unfortunately, despite considerable efforts, validated ESC lines in species other than mice and primates are yet to be isolated. In this paper, we will summarize the current knowledge on bovine ESCs in an attempt to understand why derivation of domestic animal ESC is still unsuccessful and we will discuss some promising future approaches.