Twenty Years of Embryonic Stem Cell Research in Farm Animals
Article first published online: 25 JUL 2012
© 2012 This article is a U.S. Government work and is in the public domain in the USA.
Reproduction in Domestic Animals
Special Issue: Proceedings of the 17th International Congress on Animal Reproduction (ICAR)
Volume 47, Issue Supplement s4, pages 80–85, August 2012
How to Cite
Blomberg, L. and Telugu, B. (2012), Twenty Years of Embryonic Stem Cell Research in Farm Animals. Reproduction in Domestic Animals, 47: 80–85. doi: 10.1111/j.1439-0531.2012.02059.x
- Issue published online: 25 JUL 2012
- Article first published online: 25 JUL 2012
Notable distinctions between an embryonic stem cell (ESC) and somatic cell are that an ESC can maintain an undifferentiated state indefinitely, self-renew, and is pluripotent, meaning that the ESC can potentially generate cells representing all the three primordial germ layers and contribute to the terminally differentiated cells of a conceptus. These attributes make the ESC an ideal source for genome editing for both agricultural and biomedical applications. Although, ESC lines have been successfully established from rodents and primates, authentic ungulate stem cell lines on the contrary are still not available. Outstanding issues including but not limited to differences in pluripotency characteristics among the existing ESC lines, pre-implantation embryo development, pluripotency pathways, and culture conditions plague our efforts to establish authentic ESC lines from farm animals. In this review, we highlight some of these issues and discuss how the recent derivation of induced pluripotent stem cells (iPSCs) might augur the establishment of robust authentic ESC lines from farm animals.