Vesiculobullous Hailey-Hailey disease: Successful treatment with oral retinoids

Authors

  • Michelle J Hunt,

    1. Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Search for more papers by this author
    • MJ Hunt, MMed. ELC Salisbury. FRCPA. DM Painter, FRCPA. S Lee, FACD.

  • Elizabeth LC Salisbury,

    1. Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Search for more papers by this author
    • MJ Hunt, MMed. ELC Salisbury. FRCPA. DM Painter, FRCPA. S Lee, FACD.

  • Dorothy M Painter,

    1. Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Search for more papers by this author
    • MJ Hunt, MMed. ELC Salisbury. FRCPA. DM Painter, FRCPA. S Lee, FACD.

  • Stephen Lee

    Corresponding author
    1. Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Search for more papers by this author
    • MJ Hunt, MMed. ELC Salisbury. FRCPA. DM Painter, FRCPA. S Lee, FACD.


Dr S Lee, Department or Dermatology, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW 2050. Australia.

SUMMARY

A 56-year-old male presented with a pruritic, generalized vesiculobullous eruption. His past history revealed classical symptoms of limited Hailey-Hailey disease for 34 years. Clinically, vesicles, bullae and occasional pustules were present and multiple biopsies confirmed this to be an unusual presentation of Hailey-Hailey disease. Various therapeutic modalities including topical and oral antibiotics, oral prednisone and dapsone failed to achieve sustained remission. Treatment with lowdose oral etretinate (25 mg daily) produced marked clinical improvement with complete suppression of new vesicle formation after 6 weeks.

Ancillary