Granular cell basal cell carcinoma


  • Pavel Dundr, MD. JiříŠtork, MD. Ctibor Povýšil, MD. František Vosmík, MD.

    Funding for colour figure publication was provided by the Australasian Dermatopathology Society.

    Manuscripts for this section should be submitted to Assoc. Prof. S Kossard.

Dr Pavel Dundr, Department of Pathology, Studničkova 2, 128 00 Prague 2, Czech Republic. Email:


A 69-year-old woman presented with a 2-year history of a slowly growing tumour on the nose. The clinical diagnosis was basal cell carcinoma (BCC) and a complete excision was performed. Histologically, the tumour had the general features of a BCC but with sheets and nests of cells with granular cytoplasmic changes in the centre of the lesion. A pathological diagnosis of granular cell BCC was made. On immunohistochemical examination, the tumour cells were Ber-EP4, cytokeratin AE1/AE3 and cytokeratin CAM 5.2 positive but S100 protein negative. Only the granular cells were CD68 antigen (monoclonal antibody KP1) positive.