Shannon Harrison, MB BS. Rodney Sinclair, FACD.
Hypotrichosis and nail dysplasia: A novel hidrotic ectodermal dysplasia
Article first published online: 7 APR 2004
Australasian Journal of Dermatology
Volume 45, Issue 2, pages 103–105, May 2004
How to Cite
Harrison, S. and Sinclair, R. (2004), Hypotrichosis and nail dysplasia: A novel hidrotic ectodermal dysplasia. Australasian Journal of Dermatology, 45: 103–105. doi: 10.1111/j.1440-0960.2004.00055.x
- Issue published online: 7 APR 2004
- Article first published online: 7 APR 2004
- Submitted 23 June 2003; accepted 30 October 2003.
- trichorrhexis nodosa
We report a unique isolated hair and nail ectodermal dysplasia in a 3-year-old girl. Clinical examination revealed short, sparse scalp hair, absent eyebrows, short eyelashes and nail dystrophy in all digits. Nail changes included shortened nail plate with distal onycholysis and loss of the cuticle. Sweating and teeth were normal. Development was normal. Scanning electron microscopy of the hair only demonstrated trichorrhexis nodosa. There was no pili torti. Vertically sectioned scalp biopsy revealed hypoplastic hair follicles and a horizontally sectioned biopsy showed a decrease in the overall number of hair follicles present. Treatment with topical minoxidil 5% 1 mL twice each day massaged into the scalp led to only minimal improvement and was discontinued after 12 months.