Sheikh Javeed Sultan, MD. Qazi Masood Ahmad, MD. Sheikh Tariq Sultan, MB BS.
Antigliadin antibodies in psoriasis
Article first published online: 16 NOV 2010
© 2010 The Authors. Australasian Journal of Dermatology © 2010 The Australasian College of Dermatologists
Australasian Journal of Dermatology
Volume 51, Issue 4, pages 238–242, November 2010
How to Cite
Sultan, S. J., Ahmad, Q. M. and Sultan, S. T. (2010), Antigliadin antibodies in psoriasis. Australasian Journal of Dermatology, 51: 238–242. doi: 10.1111/j.1440-0960.2010.00648.x
- Issue published online: 16 NOV 2010
- Article first published online: 16 NOV 2010
- Submitted 8 February 2009; accepted 22 February 2010.
- Antigliadin antibodies;
- Coeliac disease;
- Psoriatic arthritis
Background/Objectives: Although antigliadin antibodies (AGA) are markers of coeliac disease, elevated levels of these antibodies are also seen in many other autoimmune, neurological, haematological, collagen vascular and cutaneous disorders, even in the absence of clinically overt gastrointestinal disease. Several studies have reported an association between psoriasis and AGA, with improvement in severity of psoriasis on a gluten-free diet. This study aims to determine whether patients with psoriasis in Kashmir have an increased prevalence of elevated AGA.
Methods: A total of 120 patients (all native Kashmiris) with psoriasis and an equal number of age- and sex-matched controls without any personal or family history of autoimmune disorders were included in the study. Both groups were tested for IgA and IgG AGAs using a standard enzyme-linked immunosorbent assay method.
Results: No statistically significant difference in the prevalence of AGA among patients with psoriasis (6.67% for IgA and 4.17% for IgG) and control group individuals (7.5% IgA and 5.0% IgG) was observed. The mean AGA levels in the two groups were not statistically different. Furthermore, no significant association between AGA levels and psoriasis severity, joint involvement, age of onset of psoriasis or arthritis was observed.
Conclusions: The results of our study show that AGA are not elevated in psoriasis patients as compared with a healthy population, and there is no association between AGA and psoriasis, its onset, severity and joint symptoms.